Noorwala, Mushtaq (1995) STUDIES ON THE CHEMICAL CONSTITUENTS OF THE SEEDS OF VIGNA UNGUICULATE (LINN.), WALP SUBSP. UNGUICULATA AND THE ROOTS OF SYMPHYTUM OF OFFICINALE LINN. PhD thesis, University of Karachi, Karachi.
The work embodied in the present thesis is presented in two. Part ÃÂÃÂ¢ÃÂÃÂÃÂÃÂI describes the isolation and structure elucidation of the chemical constituents of vigna unguiculata subsp. Unguiculata belonging to the family paplilionaceae Part-I . The introduction of part-I provided a review of the earlier contribution made in the chemistry and pharmacology of the plant vigna unguiculata subsp. Unguiculata subsp unguiculata have resulted in the isolation of one new saponin which was named as vginalin (1). The aglycone part of this saponins belongs to the oleannane series of triterpenoids and identified as soyasapogenol B.Beside saponin 1, cycloartenol (2), stigmasterol (3), oleanolic acid acetate (4) and sitosterol ÃÂÃÂÃÂÃÂ²-D-glycoside (5) were also isolated for the first time form this plant. Compound 1-5 were isolated form the column chromatography of the methanolic extract of the seeds of V. unguiculata subsp. unguiculata Saponin A(1) (3-O-[ÃÂÃÂÃÂÃÂ±-L-rhamnopyranosy1-(1ÃÂÃÂ¢ÃÂÃÂÃÂÃÂ4)-ÃÂÃÂÃÂÃÂ²-D-galactopyranosy1-(1ÃÂÃÂ¢ÃÂÃÂÃÂÃÂ4)-ÃÂÃÂÃÂÃÂ²-D-glucuronopyranosy1]-soyasapogeno1 B. J.Nat. Prod,58(7), 1070(1995) The Par-II of the thesis deals with the isolation and structural elucidation of three new pentqacyclic triterpenoidal saponin named as saponin I (9), saponin J(10) and saponin K (11) isolation form the roots of symphytum officinale L. (Boraginaceae). The aglycone of all the above three saponins is hederagenin. Two pyrrolizidine alkaloids L (12) (Otosenine) and M(13) (senciphylline) alkaloid L (12) and M (13) have already been reported earlier but isolation for the first time from this plantÃÂÃÂ¢ÃÂÃÂÃÂÃÂ¦ÃÂÃÂ¢ÃÂÃÂÃÂÃÂ¦ÃÂÃÂ¢ÃÂÃÂÃÂÃÂ¦. Extensive spectroscopic techniques such as EIMS, FDMS, FABMS, HRMS,UV, IR, 1H- and 13C0NMR, 2D-NMR (COSY-450,, NOESY, HeteroCOSY, HMQC, HOHAHA 2D J-resolved) and chemical reactions were employed to elucidate the structures of the compounds noted in Part-I and Part-II. DEPT experiments were also carried out to determine the multiplicities of the carbon atoms.
|Item Type:||Thesis (PhD)|
|Uncontrolled Keywords:||vigna unguiculate (linn.), walp subsp. unguiculata, symphytum officinale l., paplilionaceae, saponins, triterpenoids, pyrrolizidine alkaloids|
|Subjects:||Physical Sciences (f) > Chemistry(f2)|
|Deposited By:||Mr. Muhammad Asif|
|Deposited On:||24 Nov 2006|
|Last Modified:||04 Oct 2007 21:03|
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