I= ISOLATION AND STRUCTURAL STUDIES ON THE NEMATICIDAL CONSTITUENTS OF DATURA FASTUOSA AND CHEMICAL CONSTITUENTS OF BONGARDIA CHRYSOGONUM AND RHAZYA STRICTA
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Title of Thesis
ISOLATION AND STRUCTURAL STUDIES ON THE NEMATICIDAL CONSTITUENTS OF DATURA FASTUOSA AND CHEMICAL CONSTITUENTS OF BONGARDIA CHRYSOGONUM AND RHAZYA STRICTA

Author(s)
Durre Shahwar
Institute/University/Department Details
H.E.J Research Institute of Chemistry/ University of Karachi
Session
1997
Subject
Chemistry
Number of Pages
186
Keywords (Extracted from title, table of contents and abstract of thesis)
datura fastuosa, bongardia chrysogonum, rhazya stricta, saponins, nematicidal bioassay

Abstract
This thesis is composed of two parts; part A describes phytochemical analysis plants namely Bongardia chrysogonum and rhazya stricta which resulted in the isolation and characterization of nine new constituents. In addition, seven known compounds are also isolation for the first time form the genus Bongardia. It is known that more than one type of alkaloids have been isolated from different plants. This is a unique example of the isolation of three different types of alkaloids from the same plant source. The new compounds isolation from B. chrysogonum are bonzakaline (1), 17-desoxo-cis-lamphroobine (2) , bongardine (3), acetyl bongardine (4), bongardamine (5), 3-O-[β-D-glucopyranosy1-(1→4)-β-D-glucopyransoy1-(1→4)-α-L-arabinopyransoy1]- hederagenine (9). Seven known compounds are also isolated from the same species namely palmatrubine(6), lupanine (7), symphytoxide (10), leontoside D(11), 3-O-[β-D-glucopyransoy1-(1→4)- α-L-arabinopyransoy1]- hederagenine 28-O-[β-D-glucopyranosy1-(1→6)-β-D-glucopyransoy1] ester(12) hederacoside A (13) and leontoside A(14). Two new compounds isolated from rhazya stricta are 9-octadecenoic acid-(Z)-2-3-dihydroxyproy1 ester(15) and hexadecanoic acid-2-3- dihydroxyproy1 ester (16). Structure elucidation of the compounds was carried out by using different techniques including 1H-nmr, 13C, HMQC, HOHAHA and COSY 450. The substitution pattern was confirmed by NOE measurements. Stereo chemical assignments were made by applying Horeau’s horeau’s methods.

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1713.85 KB
S. No. Chapter Title of the Chapters Page Size (KB)
1 0 Contents
88.74 KB
2 1 Introduction 1
228.46 KB
  1.1 Bongardia Chrysogonum 1
  1.2 Rhazya Stricta 18
3 2 Results And Discussion 23
949.89 KB
  2.1 Alkaloids From The Tubers Of Bongardia Chrysogonum 23
  2.2 Saponins From The Tubers Of Bongardia Chrysogonum 61
  2.3 Fatty Esters From The Roots Of Rhazya Stricta 107
4 3 Experimental 120
311.61 KB
  3.1 General Experimental Conditions 120
  3.2 Bongardia Chrysogonum 120
  3.3 Rhazya Stricta 148
5 4 Isolation Of Nematicidal Compounds From Datura Fastuosa Introduction 153
26.88 KB
  4.1 Datura Fastuosa 154
6 5 Results And Discussion 155
120 KB
  5.1 In-Vitro Studies 155
  5.2 In-Vivo Pot Studies 164
7 6 Experimental 166
215.9 KB
  6.1 Plant Material 166
  6.2 Extraction And Purification 166
  6.3 In-Vitro Nematicidal Bioassay 175
  6.4 In-Vivo Pot Experiment 176
  6.5 References 179