Qazi, Sobiha (1987) STUDIES ON CHEMICAL CONSTITUENTS OF PROSOPIS JULFLORA AND CLEOME PRACHYCARPA. PhD thesis, University of Karachi, Karachi.
The present thesis is divided into two parts. The first part is entitled as ÃÂÃÂ¢ÃÂÃÂÃÂÃÂStudies on Chemical Constituents from Prosopis JulifloraÃÂÃÂ¢ÃÂÃÂÃÂÃÂ The isolation of seven new piperidine alkaloids namely projulinine, projuline juline juliflorinine, isoprojuline juliflorinine and isojuliprosine is described. Three more alkaloids namely juliflorine (juliprosopine), julifloridine and juliprosine already reported earlier from this plant have also been isolated. The absolute configuration of julifloridine is suggested. The structure of juliflorinine is estrablished and the structures of projulinine, projuline julifloricine and isoprojuline are proposed. The antifungal and antibacterial activities of juliflorine julifloricine and benzene insoluble alkloids are studied. Juliflorine is tested fro its antifungal activity against the freshly isolated cultures of dermatophytic fungi and tis inhibitory effect is compared with that of griseofulvin. It is concluded that juliflorine and julifloricine is more effective than many known antibiotics. Strep tococcus faecalis is found to resistant all antibiotic used except juliflorine and anpicillin. Juliflorine is also more effective than penicillin sulphamethoxazole and erythromycin against Staphylococcus aureus. Julifloricine, a new alkaloid from this plant also exhibited significant zones of inhibition as compared to penicillin against S. aureus and S. pyrogemes. S. Faecalis is found resistant to pencillin gentamicin and trimethoprim but sensitive to julifloricine and penicillin. The activeity of benzene isoluble mixture was determind in vitro against 22 bacteria. It is found to be significantly effective against most gram positive bacteria than antibiotics bacitractin gentamicin chloromycetin and trimethoprim against S.aureus, S.Lactis S. Faecalis, S. Pyogenes and C. Diptherice var. mities. The mixute is more effective on B. Subtilis than other antibiotics compared and as effective as gentamicin and chloromycetin. Details of the work on antimicrobial activities are discussed in chapter-5. The second part of the thesis deals with the ÃÂÃÂ¢ÃÂÃÂÃÂÃÂStudies on chemical constituents from ceeome brachycarpaÃÂÃÂ¢ÃÂÃÂÃÂÃÂ A new triterpene cleocarpone was isolated along with other reported and unreported compound. The structure of cleocarpone is established by spectral data as well as through X-ray crystallography. It is a new member of the demmarane group of triterpenes.
|Item Type:||Thesis (PhD)|
|Uncontrolled Keywords:||prosopis julflora, cleome prachycarpa, piperidine alkaloids, projulinine, projuline juline juliflorinine, isoprojuline juliflorinine, isojuliprosine, triterpene cleocarpone, demmarane group, triterpenes|
|Subjects:||Physical Sciences (f) > Chemistry(f2)|
|Deposited By:||Mr. Muhammad Asif|
|Deposited On:||24 Nov 2006|
|Last Modified:||04 Oct 2007 21:03|
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