I= PHYTOCHEMICAL AND STRUCTURAL STUDIES ON THE CHEMICAL CONSTITUENTS OF ALSTONIA MACROPHYLLA AND SOLANUM ALBICAULE
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Title of Thesis
PHYTOCHEMICAL AND STRUCTURAL STUDIES ON THE CHEMICAL CONSTITUENTS OF ALSTONIA MACROPHYLLA AND SOLANUM ALBICAULE

Author(s)
Farzana Nighat
Institute/University/Department Details
H.E.J Research Institute of Chemistry/ University of, Karachi
Session
1992
Subject
Chemistry
Number of Pages
196
Keywords (Extracted from title, table of contents and abstract of thesis)
alstonia macrophylla, solanum albicaule, alkaloids, indole alkaloids, a. macrophylla, s. albicaule, albecauline

Abstract
Chemical investigations on the leaves of Alstonia macrophylla and Solanum albicaule are presented in this thesis.

The research work on the alkaloidal contents of the leaves of A. macrophylla (part A) has led to the isolation and characterization of twelve indole alkaloids. Of these eight were new , two were new form this source and remaining two were reported.

1Macroxine 70 Tetrahedron, 47,3129(1991) 2alstopicralamine 75 Heterocycles, 27(4), 961(1988) 3Alstoumerine 81 J.Nat prod.,54(3),750(1991) 410-Hydroxystrictamine 90 Heterocycles,(Submitted) 5Alstozine N-oxide 92 Fitoterapia, LI (3) 230(1990) 6Alstomacrocine 94 Heterocycles,(submitted) 7Isoalstopicralamine 99(Tentative structure) 8Alstomacroline 100

Known alkaloids (unreported form A. macrophylla) 1Vincamajine102 2Alstonisine 103 Known alkaloids form A. macrophylla 1Qenbrachidine 104 2Nb- Demethlalstophyllineoxindole 105

The structures of all these alkaloids have been elucidated on the basis of modern spectroscopic techniques such as ID and 2D-nmr (COSY, NOE, HOHAHA, 13C-nmr), inverse nmr experiments (HMQC, HMBC), mass spectroscopic techniques (EI, FD, FAB, HR), IR and UV spectra.

1Albecauline 17 (Tentative structure)

Download Full Thesis
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S. No. Chapter Title of the Chapters Page Size (KB)
1 0 Contents
75.75 KB
2 1 General Introduction 6
14.77 KB
3 2 Alkaloids 8
138.62 KB
  2.1 Introduction 8
  2.2 Biosynthesis Of Indole Alkaloids 12
4 3 Alstonia Macrophylla 27
1031.27 KB
  3.1 Introduction 28
  3.2 Results And Discussion 46
  3.3 Reported Alkaloids Isolation For The First Time From The Leaves Of A. Macrophylla 129
  3.4 Reported Alkaloids From The Leaves Of A. Macrophylla 136
5 4 Experimental 144
176.99 KB
  4.1 General Experimental Conditions 145
  4.2 Techniques Employed For The Purification Of Alkaloids 146
  4.3 Isolation Of Alkaloids Form The Leaves Of A. Macrophylla 147
6 5 Literature Cited 161
147.66 KB
7 6 Introduction 176
47.72 KB
  6.1 Steroidal Alkaloids 177
  6.2 Biosynthesis Of Steroidal Alkaloids 177
8 7 Solanum Albicaule 183
51.8 KB
  7.1 Introduction 184
  7.2 New Alkaloid Of An Form The Leaves Of S. Albicaule 184
9 8 Experimental 189
43.88 KB
  8.1 Isolation Of An Alkaloid From The Leaves Of S. Albicaule 190
  8.2 Isolation Of Albecauline 191
10 9 Literature Cited 193
25.87 KB