I= ISOLATION AND STRUCTURAL STUDIES ON THE ALKALOIDS OF CATHARANTHS ROSEUS
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Title of Thesis
ISOLATION AND STRUCTURAL STUDIES ON THE ALKALOIDS OF CATHARANTHS ROSEUS

Author(s)
Irshad Ali
Institute/University/Department Details
H.E.J Research Institute of Chemistry/ University of Karachi
Session
1985
Subject
Chemistry
Number of Pages
144
Keywords (Extracted from title, table of contents and abstract of thesis)
alkaloids, catharanths roseus, sada bahar, apocynaceaes, bannucine gomaline, rosamine, c. roseus, indole alkaloids

Abstract
Catharanthus of roseus (L) G.DON locally known as “Sada bahar” is widely distributed throughout Pakistan. It is one of the most thoroughly investigated plants of Apocynaceaes and over 120 alkaloids of different types have been isolated form it. This Ph.D thesis described the isolation and structure elucidation of three new alkaloids, “bannucine gomaline and rosamine”. Three other compounds isolated have been identified as rhazimol, cathovaline and Catharine. Rhazimol and cathovaline have not previously been reported form this plant. A detailed study on the 1H and 13C-NMR spectra of Catharine have provided insights into the conformations of the molecule in solution.

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1195.83 KB
S. No. Chapter Title of the Chapters Page Size (KB)
1 0 Contents
45.83 KB
2 1 Introduction 1
261.56 KB
  1.1 Indole Alkaloids 3
  1.2 Biosynthesis 7
3 2 Catharanthus Roseus 32
68.2 KB
  2.1 Alkaloids Obtained From Catharanthus Roseus (L) G.Don 35
4 3 Fractionation Procedure Catharanthus Roseus ( L) G.Don 40
14.96 KB
5 4 Alkaloids From The Leaves Of Catharanthus Roseus ( L) G.Don 41
475.44 KB
  4.1 Bannucine –A New Dihydroindole Alkaloid For Catharanthus Rosues ( L) G.Don 41
  4.2 Gomaline –A New Indolenine Alkaloid From Catharanthus Roseus (L) G.Don 61
  4.3 Rosamine –A New Pseudoindoxyl Alkaloid From Catharanthus Roseus (L) G.Don 65
  4.4 Mass And Nmr Spectroscopic Studies On Catharine-An Alkaloid From Catharanthus Roseus (L) G.Don 72
  4.5 Isolation And C-13 Nmr Studies On Cathovaline - And Alkaloid From Catharanthus Roseus (L) G.Don 83
  4.6 Isolation Of Rhazimol Form The Leaves Catharanthus Roseus (L) G.Don 90
6 5 Alkaloid In Flowers Of Catharanthus Roseus (L) G.Don 93
127.28 KB
  5.1 Isolation Of Coronaridine And 11-Methody-Tabaersonine 94
  5.2 Isolation Of Tetrahydroalstonine , Ajmalicine And Vindorosine 96
  5.3 Isolation Of Catharathine , Mitraphylline And Vindoline 99
  5.4 Isolation Of Vinblastine 102
7 6 Experimental General Notes 105
148.62 KB
  6.1 Bannucine –A New Dihydroindole Alkaloid From Catharanthus Roseus (L) G.Don 106
  6.2 Gomaline –A New Indolenine Alkaloid From Catharanthus Roseus (L) G.Don 111
  6.3 Rosamine –A New Pseudoinoxyl Alkaloid From Catharanthus Roseus (L) G.Don 112
  6.4 Mass And Spectroscopic Studies On Catharine- An Alkaloid From Catharanthus Roseus (L) G.Don 113
  6.5 Isolation And C-13 Nmr Studies On Cathovaline –An Alkaloid From Catharanthus Roseus (L) G.Don 116
  6.6 Isolation Of Rhazimol From The Leaves Catharanthus Roseus (L) G.Don 117
8 7 Alkaloids In Flowers Of Catharanthus Roseus (L) G.Don 120
234.52 KB
  7.1 Coronaridine And 11-Methoxy – Tabersonine 120
  7.2 Tetrahydroalstonine , Ajmalicine And Vindorosine 122
  7.3 Catharanthine , Mitrapyhylline And Vindoline 123
  7.4 Vinblastine 125
  7.5 References 126
  7.6 Publications 144