I= PHYTOCHEMICAL STUDIES ON TAXUS WALLICHIANA ZUCC., PODOPHYLLUM EMODI VAR. HEXANDRUM AND RELATED MEDICINAL PLANTS
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Title of Thesis
PHYTOCHEMICAL STUDIES ON TAXUS WALLICHIANA ZUCC., PODOPHYLLUM EMODI VAR. HEXANDRUM AND RELATED MEDICINAL PLANTS

Author(s)
Muhammad Ashraf
Institute/University/Department Details
University of Karachi/ H.E.J. Research Institute of Chemistry
Session
1999
Subject
Chemistry
Number of Pages
191
Keywords (Extracted from title, table of contents and abstract of thesis)
taxus wallichiana zucc., podophyllum emodi var. hexandrum, medicinal plants, podophyllum emodivar hexandrum (royle), lignans,

Abstract
The present doctoral work deals with the isolation of chemical constituents from two medicinally important plants namely, Taxus wallichiana Zucc. And Podophyllum emodi var. hexandrum collected from the northern areas of Pakistan.

Phytochemical investigations on the aerial parts of Taxus wallichiana Zucc. Led to the isolation of three new metabolites, 5a-hydroxy-1B, 7B, 9a, 10B, 13a-pentaacetoxy-4(20)-taxa-11(12)-diene (142), 15-acetyl-11)15-1)-abeo-taxane (143), and 5a, 7B, 9a, 10B-tetrahydroxy-1(15-11)-abeo-taxa-4(20)-12-diene(144)along with two known taxiods, 1B-hydroxy-7,9-deacetylbaccatin 1 (145) and 5-decinnamate taxagifine (146) reported earlier from T. conadesis.

Download Full Thesis
2500.61 KB
S. No. Chapter Title of the Chapters Page Size (KB)
1 0 Contents/ Summary
111.96 KB
2 1 Introduction 1
204.52 KB
  1.1 General Introduction 1
  1.2 Logical protocol for structure elucidation and rapid Dereplication of natural products 7
3 2 Taxus wallichiana zucc 14
1151.65 KB
  2.1 Introduction 14
  2.2 Classification 17
  2.3 Pharmacological properties of taxanes 25
  2.4 Literature survey 31
  2.5 Biosynthesis of taxanes 42
  2.6 Results and Discussion 54
4 3 Podophyllum emodivar hexandrum (royle) 100
706.67 KB
  3.1 Introduction 100
  3.2 Pharmacological properties of lignans 102
  3.3 Biosynthesis of lignans 113
  3.4 Results and Discussion 124
5 4 Experimental 154
554.99 KB
  4.1 General experimental conditions 153
  4.2 Isolation of taxanes from taxus wallichiana zucc 155
  4.3 Isolation of lignans from podophyllum hexandrum Royle 164
  4.4 Pharmacology 172
  4.5 References 173