I= ISOLATION AND STRUCTURE ELUCIDATION OF CHEMICAL CONSTITUENTS OF THE BIOLOGICALLY ACTIVE FRANCTIONS OF VERTRUM SPECIES
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Title of Thesis
ISOLATION AND STRUCTURE ELUCIDATION OF CHEMICAL CONSTITUENTS OF THE BIOLOGICALLY ACTIVE FRANCTIONS OF VERTRUM SPECIES

Author(s)
Rahat Sultana
Institute/University/Department Details
University of Karachi/ H.E.J. Research Institute of Chemistry
Session
1993
Subject
Chemistry
Number of Pages
252
Keywords (Extracted from title, table of contents and abstract of thesis)
vertrum species, alkaloids, steroidal alkaloids, veratrum alkaloids, vertrum album

Abstract
This thesis describes the isolation and structure elucidation of chemical constituents of the biologically active fractions of veratrum album. Chemical and pharmacological investigations of veratrum album have led to the isolation of ten new steroidal alkaloids and invitro antihypertensive testing of three new steroidal bases. Moreover a known steroidal alkaloid have been isolated, the spectral studies on which are reported for the first time. In addition one known steroidal alkaloid previously unreported from Veratrum album is discussed. Their structures were established on the basis of UV, IR, mass spectrometry, and ID 2D and inverse NMR techniques.

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1646.95 KB
S. No. Chapter Title of the Chapters Page Size (KB)
1 0 Contents
87.8 KB
2 1 Introduction 1
565.08 KB
  1.1 Alkaloids 3
  1.2 Steroidal Alkaloids 7
  1.3 Veratrum Alkaloids 9
  1.4 Medicinal Importance Of Veratrum Alkaloids 39
  1.5 Some Generalizations Of Spectral Data Of Veratrum Alkaloids 41
  1.6 Biosynthesis 62
3 2 Results And Discussion 84
947.6 KB
  2.1 New Alkaloids From Vertrum Album 85
  2.2 Spectroscopic Data Reported For The First Time For Known Alkaloid 194
  2.3 Unreported Alkaloids From Vertrum Album 201
4 3 Experimental 208
206.9 KB
  3.1 General Experimental Conditions 209
  3.2 Plant Material 210
  3.3 Extraction And Purification Of Rhizomes 210
  3.4 Compounds From The Rhizomes Of Vertrum Album 211
  3.5 Extraction And Purification Of Steroidal Alkaloids From The Leaves Of Veratrum Album 228
  3.6 Measurement Of Blood Pressure 234
5 4 References 235
130.35 KB
  4.1 List of Publications