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INVESTIGATION OF THE CHEMICAL CONSTITUENTS OF PROSOPIS JULIFLORA AND CIRCULAR DICHROISMIC STUDIES OF CHOLESTANQUINOXALINES

Zia, Nadeem Bin (1992) INVESTIGATION OF THE CHEMICAL CONSTITUENTS OF PROSOPIS JULIFLORA AND CIRCULAR DICHROISMIC STUDIES OF CHOLESTANQUINOXALINES. PhD thesis, University of Karachi, Karachi.

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Abstract

The present work represented in this thesis consists of two parts. The first part (PART-1) is entitled as “Investigation of chemical constituents of Prosopis juliflora” and the second part (PART-2) is related to the “Circular dichroismic studies of cholestanoquinoxalines”. The first part (PART-1) is related to natural product chemistry. This work involved isolation of two new piperidine alkaloids from a pharmacologically active plant Prosopis juliflora. The names given to these alkaloids were prosoflorine and prosinine. The structure elucidationof these alkaloids involved spectroscopic techniques like UV, IR, Mass, 1H-NMR and 13C-NMR etc. Two already known alkaloids from the same plants namely juliprosine and isojulprosine were the isolated but not included in this thesis. The second part (PART-2) of this thesis was carried out in Lehrstuhl fur Struktur Chemie, Ruhr Universitaet 4630, Bochum, W. Germany. This part of work was assigned to me by Prof. Dr. Dr. Guenther Snatzke (Late). After him unfortunately no body was there to supervise me for the interpretation of CD-spectra of cholestanoquinoxalines. All the cholestanoquinoxalines were synthesized an determined on the basis of spectroscopy. Their CD spectra were examined on the basis of all the available rules. But the CD spectra of cholestanoquinoxalines most nearly followed the helicity rule. The helicity rule includes P-helicity and M-helicity. All the cholestanoquinoxalines revealed 1La, 1Lb and 1Bb band in CD spectra as well as in UV-spectra of Cholestanoqinoxalines which followed P-helicity gave positive Cotton effects and those which followed M-elicity rule revealed negative Cotton effect. With the interpretation of the CD-spectra it was possible to determine the exact configuration of cholestane. Ultimately this work was strongly and positively supported by Prof. Dr. Hans Georg Kuball, Fachbereich Chemie der Universitaet Kaiserslautern, 6750 Kaiserslauterm. W. Germany.

Item Type:Thesis (PhD)
Uncontrolled Keywords:prosopis juliflora, cholestanquinoxalines, prosoflorine, prosinine, namely juliprosine, isojulprosine, genus prosopis, coninine, aliphatic chain
Subjects:Physical Sciences (f) > Chemistry(f2)
ID Code:902
Deposited By:Mr. Muhammad Asif
Deposited On:10 Nov 2006
Last Modified:04 Oct 2007 21:03

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