I= TERPENIC CONSTITUENTS OF PEROVESKIA ABROTANOIDES AND DIRECTING EFFECTS IN MICROBIOLOGICAL HYDROXYLATION OF STEROIDS
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Title of Thesis
TERPENIC CONSTITUENTS OF PEROVESKIA ABROTANOIDES AND DIRECTING EFFECTS IN MICROBIOLOGICAL HYDROXYLATION OF STEROIDS

Author(s)
Aslam Parvez
Institute/University/Department Details
University of Karachi/ H.E.J. Research institute of Chemistry
Session
1996
Subject
Chemistry
Number of Pages
208
Keywords (Extracted from title, table of contents and abstract of thesis)
terpenic constituents, peroveskia abrotanoides, microbiological hydroxylation, steroids, cephalosporium aphidicola, terpenoids, perovskone (43), peradione (45), labda-7, b-amyrin (47), germanicol (48), lupcol (49), olenolic acid (52)

Abstract
The work embodied in this thesis has been divided into two parts. The structure elucidation and characterization of terpenic constituents isolated from perovskia abrotanoides Kiril (syn. P. artemisoides Boiss) have been included in PART-A. This work was completed under the supervision of Prof: Viqar Uddin Ahmad, Co-Director, H.E.J. Research Institute of Chemistry, University of Karachi.

The PART-B of this thesis is concerned with the microbiological hydroxylation of steroids by Cephalosporium aphidicola. The biotransformation work was done under the guidance of Dr. J.R. Hanson in the School of Chemistry and Molecular Sciences, University of Sussex, England, as a part of link programme between H.E.J. Research Institute of Chemistry, University of Karachi and University of Sussex.

(PART-A). Terpenic constituents of pervskia abrotaniodes Kiril (Syn. P. artemisoides Boiss).

The PART-A is composed of three chapters. The first chapter describes the general introduction, biosynthesis of terpenoids and literature survey on Pervskia genus with special emphasis on the phytochemical studies of perovskia abrotanoides.

The second chapter deals with the present work which describes the structure elucidation of the terpenoids isolated from perovskia abrotanoids.

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S. No. Chapter Title of the Chapters Page Size (KB)
1 0 Contents/ Summary
102.21 KB
2 1 Part A:-General Introduction 1
987.66 KB
  1.1 Significance of Natural products in organic chemistry 2
  1.2 The terpenoids 3
  1.3 Phytochemical studies of the Genus Perovskia 31
  1.4 Results and Discussions 34
  1.5 Terpenoids from perovskia abrotanoides 35
  1.6 Structural Elucidation of perovskone (43) 35
  1.7 Structure Elucidation of peradione (45) 61
  1.8 Structure Elucidation of Labda-7, 14-dien-13B-0l (46) 76
  1.9 Structure Elucidation of B- Amyrin (47) 84
  1.10 Structure Elucidation of Germanicol (48) 86
  1.11 Structure Elucidation of Lupcol (49) 88
  1.12 Structure Elucidation of B- Sitosterol (50) 91
  1.13 Structure Elucidation of Stigmasterol (51) 93
  1.14 Structure Elucidation of Olenolic acid (52) 95
  1.15 Structure Elucidation of 5-Hydroxy-4 ,7 -dimethoxy flavone (53) 98
  1.16 General Experimental Details 101
  1.17 Plant material 103
  1.18 Extraction procedure 103
  1.19 Isolation and characterization of terpenolids from perovskia Abrotaneoides 104
  1.20 References 114
3 2 Part-B :- Intro 120
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  2.1 Introduction 120
  2.2 Types of Biotransformation 122
  2.3 Mechanism of microbiological Hydroxylation 123
  2.4 Hydroxylation of Setroids 127
  2.5 Directing effects in the Microbiological hydroxylation of Steroids 128
  2.6 The hydroxylation of steroids by cephalosporium Aphidicola 141
  2.7 Introduction 149
  2.8 Results and Discussion 150
  2.9 Biotransformation of the Substrates by Cephalosporium Aphidicola 158
  2.10 General Experimental Details 184
  2.11 Preparation of substrates 185
  2.12 General procedure for feeding with Cephalosporium Aphidicola 191
  2.13 References 202
  2.14 List of Publications 208