I= ISOLATION AND STRUCTURAL STUDIES ON THE WITHANOLIDAL CONSTITUENTS OF WITHANIA COAGULANS
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Title of Thesis
ISOLATION AND STRUCTURAL STUDIES ON THE WITHANOLIDAL CONSTITUENTS OF WITHANIA COAGULANS

Author(s)
Dur-e-Shahwar
Institute/University/Department Details
H.E.J Research institute of Chemistry/ University of Karachi
Session
1999
Subject
Chemistry
Number of Pages
197
Keywords (Extracted from title, table of contents and abstract of thesis)
withanolidal constituents, withania coagulans, solanaceae family, steroidal lactone, withpakistanin, withahejrin, antifungal activity

Abstract
This disceration describes the isolation and structural studies on the steroidal lactone withanolides from Withania coagulans of the solanaceae family.

The work has resulted in the isolation of eight new withanolides along with four known withanolides.

Extensive spectroscope techniques such as EI MS, FAB, MS, HREI MS, UV, IR 1H- and 13C-NMR (BB, DEPT, COSY-450, HMBC and HMQC) were employed to elucidate the structures of below compounds.

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2109.85 KB
S. No. Chapter Title of the Chapters Page Size (KB)
1 0 Contents/ Summary
80.43 KB
2 1 Introduction 1
335.71 KB
3 1.1 Pharmaceutical Importance of Natural Products 2
335.71 KB
4 1.2 Withania coagulans 12
335.71 KB
5 1.3 Withanolides 14
335.71 KB
6 2 Boisynthesis of Withanolides 18
48.54 KB
7 3 Results and Discussion 30
1536.7 KB
  3.1 Coagulin (34)-A New Withanolide 30
  3.2 Coagulin C (37)-A New Withanolide 46
  3.3 Coagulin E (39)-A New Withanolide 62
  3.4 Coagulin A (41)-A New Withanolide 77
  3.5 Withpakistanin (43)-A New Withanolide 92
  3.6 Withpakistanin (45)-A New Withanolide 108
  3.7 17β-Hydorxywithanolide K (47)-A New Withanolide 123
  3.8 Withahejrin (48)-A New withanolide 138
  3.9 A Known Withanolide (49) 150
  3.10 A Known Withanolide (50) 153
  3.11 A Known Withanolide (51) 156
  3.12 A Known Withanolide (52) 159
  3.13 Conclusion 161
8 4 Experimental 162
163.02 KB
  4.1 General Experimental details 162
  4.2 Antifungal activity 163
  4.3 Plant Materials 166
  4.4 Extraction and purification 166
9 5 References 179
180.37 KB
  5.1 List of Publications 197