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| Pakistan Research Repository | Home |
Title of Thesis |
| Author(s) Dur-e-Shahwar |
| Institute/University/Department Details H.E.J Research institute of Chemistry/ University of Karachi |
| Session 1999 |
| Subject Chemistry |
| Number of Pages 197 |
| Keywords (Extracted from title, table of contents and abstract of thesis) withanolidal constituents, withania coagulans, solanaceae family, steroidal lactone, withpakistanin, withahejrin, antifungal activity |
Abstract The work has resulted in the isolation of eight new withanolides along with four known withanolides. Extensive spectroscope techniques such as EI MS, FAB, MS, HREI MS, UV, IR 1H- and 13C-NMR (BB, DEPT, COSY-450, HMBC and HMQC) were employed to elucidate the structures of below compounds. |
| Download Full Thesis |  2109.85 KB |
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| S. No. | Chapter | Title of the Chapters | Page | Size (KB) |
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| 1 | 0 | Contents/ Summary | 80.43 KB |
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| 2 | 1 | Introduction | 1 | 335.71 KB |
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| 3 | 1.1 | Pharmaceutical Importance of Natural Products | 2 | 335.71 KB |
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| 4 | 1.2 | Withania coagulans | 12 | 335.71 KB |
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| 5 | 1.3 | Withanolides | 14 | 335.71 KB |
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| 6 | 2 | Boisynthesis of Withanolides | 18 | 48.54 KB |
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| 7 | 3 | Results and Discussion | 30 | 1536.7 KB |
| 3.1 | Coagulin (34)-A New Withanolide | 30 | ||
| 3.2 | Coagulin C (37)-A New Withanolide | 46 | ||
| 3.3 | Coagulin E (39)-A New Withanolide | 62 | ||
| 3.4 | Coagulin A (41)-A New Withanolide | 77 | ||
| 3.5 | Withpakistanin (43)-A New Withanolide | 92 | ||
| 3.6 | Withpakistanin (45)-A New Withanolide | 108 | ||
| 3.7 | 17β-Hydorxywithanolide K (47)-A New Withanolide | 123 | ||
| 3.8 | Withahejrin (48)-A New withanolide | 138 | ||
| 3.9 | A Known Withanolide (49) | 150 | ||
| 3.10 | A Known Withanolide (50) | 153 | ||
| 3.11 | A Known Withanolide (51) | 156 | ||
| 3.12 | A Known Withanolide (52) | 159 | ||
| 3.13 | Conclusion | 161 | ||
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| 8 | 4 | Experimental | 162 | 163.02 KB |
| 4.1 | General Experimental details | 162 | ||
| 4.2 | Antifungal activity | 163 | ||
| 4.3 | Plant Materials | 166 | ||
| 4.4 | Extraction and purification | 166 | ||
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| 9 | 5 | References | 179 | 180.37 KB |
| 5.1 | List of Publications | 197 | ||
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