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ISOLATION AND STRUCTURAL STUDIES ON THE CHEMICAL CONSTITUENTS OF BUXUS PAPILLOSA AND THE RELATED PLANTS

Nasir, Habib (1993) ISOLATION AND STRUCTURAL STUDIES ON THE CHEMICAL CONSTITUENTS OF BUXUS PAPILLOSA AND THE RELATED PLANTS. PhD thesis, University of Karachi, Karachi.

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Abstract

The work described in this thesis is based on the studies on the chemical constituents of Buxus papillosa and Buxus hildebrandtii. B. papillosa is large shrub found in the northern areas of Pakistan. Previous work on the leaves of this plant by Atta-ur-Rehman et al. has resulted in the isolation of more than 60 new alkaloids. The present work on the roots of B. popillosa has led to the isolation of six new non-nitrogenous triterpenoids: buxapentalactone (1). Buxahejrine (2). Buxatenone (3). 11a-hydroxybuxatenone (4). Buxaheptalactone (5) and buxapapillosion (6). Buxus hildebrandtii is a native of Bale province. Ethiopia. Phtochemical investigations on the leaves of this plant have resulted in the isolation of ten alkaloids (four new and six with new source): 30-O-benzoyl-16-deoxybuxidienine-C (7) Nb-demethyl-30-O-benzoy1-16-deoxybuxidienine-C (8). 30-norbuxamine-A (9). 30-hydroxybuxamine-A (10), buxamine-A (11), cyclorolfeine (12), moenjodaramine (13), buxamine-C (14), cyclomicrobuxamine (15) and cyclobuxo-viridine (16). Modern spectroscopic techniques (X-ray. ID NMR, 2D NMR, EIMS, HREIMS, FD, FAB, UV and IR) were used to establish the structures of the above mentioned compounds.

Item Type:Thesis (PhD)
Uncontrolled Keywords:buxus papillosa, buxus hildebrandtii, triterpenoids: buxapentalactone (1), buxahejrine (2), buxatenone (3), 11a-hydroxybuxatenone (4), buxaheptalactone (5), buxapapillosion (6)
Subjects:Physical Sciences (f) > Chemistry(f2)
ID Code:883
Deposited By:Mr. Muhammad Asif
Deposited On:01 Nov 2006
Last Modified:04 Oct 2007 21:03

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