I= STUDIES ON THE CHEMICAL CONSTITUENTS OF PETCHIA CEYLANICA AND RELATED PLANT
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Title of Thesis
STUDIES ON THE CHEMICAL CONSTITUENTS OF PETCHIA CEYLANICA AND RELATED PLANT

Author(s)
Azra Pervin
Institute/University/Department Details
University of Karachi/H.E.J Research Institute of Chemistry
Session
1990
Subject
Chemistry
Number of Pages
216
Keywords (Extracted from title, table of contents and abstract of thesis)
petchia ceylanica, sophora giriffithii, dehassia kurzil, indote, lupine, benzylisoquinoline alkaloids, lignans, indole alkaloids, lupine alkaloids

Abstract
The thesis describes studies on the chemical constituents of Petchia ceylanica, Sophora giriffithii and Dehassia kurzil. Chemical investigations on these plants have led to the Isolation of ten new indote, lupine and benzylisoquinoline alkaloids. In addition ten more known indole alkaloids, steroid and lignans have been detected for the first time from these plants. 2D NMR studies of there known components have also been carried out.

Modern spectroscopic techniques including two dimensional NMR experiments (COSY-45, 2D-J-resolved, NOESY, HeteroCOSY, HMQC, HMBC, HOHAHA) were employed to elucidate the structure of the above mentioned compounds. DEPT and GASPE experiments were carried out to determine the multiplicities of the carbon atoms. The stereochemistry of the various a symmetric centres were established by extensive NOE difference measurements.

Download Full Thesis
1750.81 KB
S. No. Chapter Title of the Chapters Page Size (KB)
1 0 Contents
109.44 KB
2 1 Introduction 1
219.46 KB
  1.1 Alkaloids 2
  1.2 Indole Alkaloids 4
  1.3 Biosynthesis of Indole Alkaloids 7
3 2. Isolation and Structural Elucidation of Indole Alkaloids 30
219.46 KB
  2.1 Introduction 31
  2.2 Results and Discussion 31
4 3 Lupine Alkaloids 86
106.84 KB
  3.1 Introduction 87
  3.2 Biosynthesis of Lupine Alkaloid 89
5 4 Isolation and Structural Elucidation of Lupine Alkaloids 101
405.52 KB
  4.1 Introduction 102
  4.2 Results and Discussion 102
6 5 Isolation and Structural Elucidation of Isoquinoline Alkaloids 141
237.8 KB
  5.1 The Bezylisoquinoline Alkaloids 142
  5.2 Results and Discussion 147
7 6 Experimental 171
419.82 KB
  6.1 General Experimental 172
  6.2 Isolation of Indole Alkaloids from Petchia Ceylanica 174
  6.3 Isolation of Lupine Alkaloids from Sophora Griffithii 189
  6.4 Isolaiton of Chemical Constituents from Dehassia Kurzii 194
  6.5 References 200
8 7 List of Publications 214
23.69 KB