I= ISOLATION AND STRUCTURAL STUDIES ON THE CHEMICAL CONSTITUENTS OF FUMARIA INDICA AND RELATED MEDICINAL PLANTS
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Title of Thesis
ISOLATION AND STRUCTURAL STUDIES ON THE CHEMICAL CONSTITUENTS OF FUMARIA INDICA AND RELATED MEDICINAL PLANTS

Author(s)
Muhammad Khalid Bhatti
Institute/University/Department Details
University of Karachi/ H.E.J Research Institute of Chemistry
Session
Subject
Chemistry
Number of Pages
229
Keywords (Extracted from title, table of contents and abstract of thesis)
fumaria indica, medicinal plants, f. flabellate, alkaloids

Abstract
During our studies on the constituents of Fumaria indica and F. flabellate, eight new alkaloids from F. Indica have been isolated and identified. These all were isoquinoline bases. In addition twenty known alkaloids have been reported for the first time from these plants and detailed spectroscopic studies were conducted. The purification of alkaloids was one by using chromatographic techniques (flash, column, thin layer, and HPLC). The structures of the alkaloids were identified on the basis of spectral data (mass, UV, IR, 1H-NMR, COSY-45o, NOE, 13C-NMR, GASPE, DEPT). The screening of crude extracts of aerial parts of F. Indica was also done.

1Papraine (133)

2Fumarizine (104)

3Papracinine (189)

4Paprarine (156)

5Paprafumine (170)

6Papracine (168)

7Papraline (94)

8Paprazine (192)

Known alkaloids Isolated for the first time from the aerial parts of F. Indica:

1Noroxyhydrastinine (95)

2Oxyhydrastinine (96)

3N-methylocorydaldine (98)

4Fumariflorine (85)

5Stylopine (110)

6Cryptopine (126)

78-oxocoptisine (107)

8Bisnorargemonine (49)

9Lastourvilline (105)

10(-)-β-hydrastine (146)

11N-methylhydrastine (155)

12Fumaramine (157)

13Parfumine (175)

14Fumaritine (176)

15Fumaritine N-oxide (190)

16N-Feruloyltyramine (193)

Alkaloid Isolated for the first time from aerial parts of F. flabellate:

1Corydaldine (97)

2Tetrahydropalmatine (70)

3Bicuculline (80)

4Fumariline (172)

Download Full Thesis
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S. No. Chapter Title of the Chapters Page Size (KB)
1 0 Contents
84.56 KB
2 1 General Introduction 1
16.25 KB
3 2 Alkaloids 3
194.41 KB
  2.1 Introduction 4
  2.2 Biosynthesis 9
4 3 Fumaria indica
947.45 KB
  3.1 Introduction 32
  3.2 Results and Discussion 55
5 4 Experimental
326.01 KB
  4.1 General Experimental Conditions 156
  4.2 Fumaria Indica 157
6 5 Results and Discussion
128.51 KB
  5.1 Reported Alkaloids Isolated for the First Time from Leaves of Fumaria , Flabellata 191
7 6 Experimental Fumaria Flabellata
66.74 KB
  6.1 Plant Material 210
  6.2 Extraction Procedure 210
8 7 References 217
108.29 KB
9 8 List of Publications 229
13.69 KB