I= ISOLATION AND STRUCTURE ELUCIDATION OF TRITERPENOIDS & OTHER CONSTITUENTS FROM ACHRAS SAPOTA
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Title of Thesis
ISOLATION AND STRUCTURE ELUCIDATION OF TRITERPENOIDS & OTHER CONSTITUENTS FROM ACHRAS SAPOTA

Author(s)
Rehana Ifzal
Institute/University/Department Details
University of Karachi/ Department of Chemistry
Session
1997
Subject
Chemistry
Number of Pages
127
Keywords (Extracted from title, table of contents and abstract of thesis)
triterpenoids, achras sapota, saponins, cotyledons, terpenes, tepenoids, non-polar extracts

Abstract
The work described in the present thesis is mainly concerned with the isolation and structural elucidation of triterpenoids and saponins presents in Achras Sapota. The thesis begins with the introduction to the Chemistry of Natural Product surveying its historical background, economic and medicinal importance. This is followed by literature survey of the plant under investigation – Achras sapota.

The Experimental Section deals with the isolations of the constituents present in the leaves, bark and the seeds (cotyledons) of Achras sapota. As a result of these investigations we have been able to isolate fourteen triterpenoids from the non-polar extracts of two parts of the plant namely the leaves and bark and five triterpenoidal saponins from the polar extracts of the seeds (cotyledons). Of the five saponins isolated in the present work, one has been previously reported in literature while the other four are been reported for the first time from this source.

The characterization of the triterpenoids and the saponins isolated is described under the section, ‘Results and Discussion’. Mainly physical methods i.e. Mass spectrometry and 1H and 13C-NMR spectroscopy were employed for the structural elucidation of the triterpenoids and the saponins. The saponins isolated have been designated as Achras saponins A,B,C,D and E.

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960.02 KB
S. No. Chapter Title of the Chapters Page Size (KB)
1 0 Contents
71.61 KB
2 1 Introduction 10
285.88 KB
  1.1 Chemistry of Natural Products 11
  1.2 Saponins 17
  1.3 Terpenes and Tepenoids 22
  1.4 Biosynthesis of Terpenoids 24
3 2 Literature Survey 46
139.36 KB
4 3 Results and Discussion 62
228.54 KB
  3.1 Characterisation of Triterpenoids 63
  3.2 Characterisation of Saponins 72
5 4 Experimental 85
297.63 KB
  4.1 General Experimental Conditions 86
  4.2 Part - 1 Isolation and Identification of Constituents In Non-Polar Extracts of Leaves 89
  4.3 Part - 2 Non Polar Constituents from the bark 98
  4.4 Part - 3 Extraction and Isolation of Saponins from Polar Fractions of Seed 102
6 5 References 120
90.27 KB