I= STUDENTS ON THE ISOLATION OF NEW POTENTIALLY BIOACTIVE AGENTS FROM RHAZYA STRICTA, FRIRILLARIA PERSICA AND RELATED PLANTS
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Title of Thesis
STUDENTS ON THE ISOLATION OF NEW POTENTIALLY BIOACTIVE AGENTS FROM RHAZYA STRICTA, FRIRILLARIA PERSICA AND RELATED PLANTS

Author(s)
Naheed Sultana
Institute/University/Department Details
University of Karachi/ H.E.J. Research Institute of Chemistry
Session
1992
Subject
Chemistry
Number of Pages
227
Keywords (Extracted from title, table of contents and abstract of thesis)
rhazya stricta, fririllaria persica, rhaziattarine (64), hexahydroalstonine (70), akuammidine (71), rhazimine(72), n-acetyl aspidosphermidine(73), eburnamenine(74), strictamine (75), rhazimanine(76), taxus baccata, persinin {137), delavinone (138), delavine (139)

Abstract
The work presented in the thesis deals with the isolation, structure elucidation and study of pharmacological properties of the four plants. Investigation on the chemical constituents of each plant is discussed in separate parts.

1) PART-A It describes the studies on the chemical constituents of the leaves of Rhazya Stricta, which have led to the isolation of two new indole alkaloids (i,ii) with six known alkaloids (iii-viii) which are as follows

Rhaziattarine (64) Hexahydroalstonine (70) Akuammidine (71) Rhazimine(72) N-acetyl aspidosphermidine(73) Eburnamenine(74) Strictamine (75) Rhazimanine(76)

2) PART-B It deals with the investigation on the chemical constituents of roots of Taxus baccata,, which led to the isolation of two new taxane diterpenoids (i,ii)and three known diterpenoids (iii-v) (i)Taxa-4(20), 11.diene-10-methoxy-2a,5a-diacetoxy-14b,a-methyl butyrate {116} (ii) Taxa-4(20),11-diene-2a-5a, 10B triacetoxy-14Bya methyl butyrate {117}

iii)Taxusin {118) (iv)2-Deacetoxy taxini J {119} (v)7B-acetoxy taxusin {120}

2) PART-C It describes the studies on the chemical constituents of Fritillaria persice This led to the isolation of one new (i) and two known alkaloids isolated for the first time from F.Persica (ii-iii).

(i)Persinin {137) (ii)Delavinone (138) (iii)Delavine (139)

4) PART-D It deals with the investigation carried on the chemical constituents of Zizyphus lotus.which led to the isolation of one new cyclopeptide alkaloid.

(i)Lotusinin {149} Extensive aspectroscopic techniques such as EIMS, FDMS, FAMBS,HRMS,Peak matching MS,UV,IR,1H and 13 C-MMR (BB,DEPT)COSY.45 , NOE difference HMBC and HMOC were employed to elucidate the structures of the above compounds.

Download Full Thesis
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S. No. Chapter Title of the Chapters Page Size (KB)
1 0 Contents
133.82 KB
2 1 Part A : Introduction 13
518.77 KB
  1.1 Biosynthesis Of Indole Alkaloids 16
  1.2 Results And Discussion 37
3 2 Part B: Introduction 87
354.98 KB
  2.1 Biosynthesis 96
  2.2 Results And Discussion 103
4 3 Part C: Intruduction 135
192.19 KB
  3.1 Biosynthesis 141
  3.2 Results And Discussion 150
5 4 Part D: Introduction 163
94.31 KB
  4.1 Biosynthesis 167
  4.2 Results And Discussion 169
6 5 Experimental: General Experimental Conditions 175
384.9 KB
  5.1 Techniques Employed For The Purification Of Alkaloids 178
  5.2 Isolation Of Rhaziattarine (64) 184
  5.3 Isolation Of Taxane Diterpenoids From Taxus Baccata 193
  5.4 Isolation Of Steroidal Alkaloids From Fritillaria Persica 200
  5.5 Isolation Of Cyclopetice Alkaloid From Zizphus Lotus 206
  5.6 References 210
  5.7 Appendix 225