I= PART-I SYNTHESIS OF AZATERPENOIDS AND THEIR BIOLOGICAL EVALUATION- PART-II STUDIES ON THE CHEMICAL CONSTITUENTS OF CUCUMIS PROPHETARUM
Pakistan Research Repository Home
 

Title of Thesis
PART-I SYNTHESIS OF AZATERPENOIDS AND THEIR BIOLOGICAL EVALUATION- PART-II STUDIES ON THE CHEMICAL CONSTITUENTS OF CUCUMIS PROPHETARUM

Author(s)
Bushra Khan
Institute/University/Department Details
University of Karachi/ Department of Chemistry
Session
1998
Subject
Chemistry
Number of Pages
112
Keywords (Extracted from title, table of contents and abstract of thesis)
azaterpenoids, cucumis prophetarum, betulin n-oxide, ursolic-n-oxide, cucuminine, prophetericin, propheterin, cyccloartanol

Abstract
This thesis comprises two parts.

Part-I:Synthesis of Azaterpenoids and their biological evaluation. Part-II:Studies on the chemical constituents of Cucumis prophetarum.

The part A describes the synthesis of Betulin N-oxide from betulin (25-29), ursolic-N-oxide from ursolic acid (30-34), and an azasteroid from a very common sterol of plant, namely, B-sistosterol (35-39).

The compounds which were synthesized are as follows:

Download Full Thesis
708.79 KB
S. No. Chapter Title of the Chapters Page Size (KB)
1 0 Contents/ Abstract
56.29 KB
2 1 Part-I :-Synthesis of Azaterpenoids and their Biologincal Evaluation 5
369.54 KB
  1.2 Introduction 6
  1.3 Experimental 12
  1.4 Isolation of Betulin 14
  1.5 Betulin Tosylate From Betulin 15
  1.6 Synthesis of Betulin Azide 15
  1.7 Synthesis of Betulin Amine 16
  1.8 Synthesis of N,N-Dimethyl Betulin Amine 17
  1.9 Synthesis of n,n-Dimethyl Betulin amine-N-Oxide 17
  1.10 Ursolic Tosylate from Urosolic Acid 17
  1.11 Synthesis of Ursolic Azide 18
  1.12 Synthesis of Ursolic Amine 18
  1.13 Preparation of 3a-N-N-dimethyl Ursolic acid 19
  1.14 N-Oxide of ursolic 3a-N-N-dimethylanime 19
  1.15 Tosylation of B-Sitosterol 20
  1.16 Azidation of B-sitosterol 20
  1.17 Reduction of sitosterol Azide 20
  1.18 N,N-dimethylation of Sitosterol amine 21
  1.19 N-Oxide Formation 21
  1.20 Results and discussions 22
  1.21 Biological Evaluation 35
  1.22 Introduction 35
  1.23 Experimental 36
  1.24 Results and Discussion 48
3 2 Part-II:-Studies on the Chemical Constiturents of Cucumis Prophetarum 55
424.34 KB
  2.1 Introduction 56
  2.2 Experimental 84
  2.3 Investigation of Fruits Cucumis prophetarum 84
  2.4 Isolation and Characterization of Constituents 85
  2.5 Cucumis prophetarum 86
  2.6 Characterization of Propheterin 88
  2.7 Characterization of Prophetericin 89
  2.8 Characterization of Cycloartanol 90
  2.9 Results and Discussion 91
  2.10 Structure Elucidation of Cyccloartanol 91
  2.11 Structure Elucidation of Propheterin 93
  2.12 Structure Elucidation of Prophetericin 94
  2.13 Structure Elucidation of Cucuminine 96
  2.14 References (Part II) 102