I= PHYTOCHEMICAL STUDIES ON THE CHEMICAL CONSTITUENTS OF SILENE CONOIDEA AND STOCKSIA BRAHUICA
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Title of Thesis
PHYTOCHEMICAL STUDIES ON THE CHEMICAL CONSTITUENTS OF SILENE CONOIDEA AND STOCKSIA BRAHUICA

Author(s)
Zulfiqar Ali
Institute/University/Department Details
University of Karachi/H.E.J. Research Institute of Chemistry
Session
1998
Subject
Chemistry
Number of Pages
183
Keywords (Extracted from title, table of contents and abstract of thesis)
silene conoidea, stocksia brahuica, stocksia brahuica benth, silene conoidea linn

Abstract
This thesis describes phytochemical investigations on the chemical constituents of two plants: Silene conoidea and Stocksia brahuica and resulted in the isolation and characterization of nine new natural products and a new derivative prepared synthetically.

In addition to new constituents, 21 known compounds have also been isolated and characterized for the first time from these species.

The new constituents isolated from Silene conoidea are conoidene (1),8(4”-o-α-L-rhamnopranosyl)-C-β-Dglucopyranosylidiosmetin (2),8(4”-o-α-L-rhamnopyraosyl)-C-β-D-glucopyranosylapigenin (3) and from Stocksia brahuic are ethyl 3, 5-dihydroxy-4-methoxybenzoate (8), 2-hydroxy-3-methylbenzoic acid (9), diphenylacetic acid (10), brahol (22) and methyl α-D-fructoside (23). A new synthetically prepared derivative is braholpentaacetate (22a).

The new source coumpounds isolated from S. conoidea are α-spinasterol (4), α-spinasterolglucoiside (5), D-pinitol (6), sucrose (7) and from S. brahuica are 3, 4, 5-trihydroxhbenzoic acid (11), 3, 4, 5-trimethoxybenzoic acid (12), methyl 4-hydroxy-3, 5-dimethoxybenzoate (13), ethyl 3, 4, 5-trihydroxybenzoate (14), methyl 4-hydroxybenzoate (15), n-propyl 4-hydroxybenzoate (16), methyl p-hydroxycinnamate (17), brahene (18), 3-O-rutinosyl-3’, 4’, 5, 7-tetrahydroxyflavone (19), 7-hydroxy-6-methoxycoumarin (20), α-tocopherol (21), ethyl β-D-glucoside (24), sucrose (25), pimaric acid (26), isopimaric acid (27), stigmasterol (28), stigmasterolglucoside (29), β-sitosterol (30) and β-sitosterolglucoside (31).

The structure elucidation of all compounds was carried out b using different spectroscopic techniques including 1H-NMR, 13C-NMR, DEPT, HMQC, HMBC, COSY-45°, nOe, EI, CI, FD, -ve and +ve FABS, IR, UV etc.

Download Full Thesis
1469.72 KB
S. No. Chapter Title of the Chapters Page Size (KB)
1 0 Contents
96.23 KB
2 1 Introduction 1
267.88 KB
  1.1 Silene Conoidea Linn 1
  1.2 Stocksia Brahuica Beth 1
  1.3 Flavonoids 2
  1.4 Benzoic Acid Derivatives 22
  1.5 Inositols 25
3 2 Results and Discussion 33
923.23 KB
  2.1 Silene Conoidea Linn 33
  2.2 Stocksia Brahuica Benth 62
4 3 Experimental 132
284.69 KB
  3.1 General Notes 132
  3.2 Silene Conoidea Linn 134
  3.3 Stocksia Brahuica Benth 144
5 4 References 170
121.97 KB
  4.1 List of Publications 181