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PHYTOCHEMICAL STUDIES ON THE CHEMICAL CONSTITUENTS OF SILENE CONOIDEA AND STOCKSIA BRAHUICA

Ali, Zulfiqar (1998) PHYTOCHEMICAL STUDIES ON THE CHEMICAL CONSTITUENTS OF SILENE CONOIDEA AND STOCKSIA BRAHUICA. PhD thesis, University of Karachi, Karachi.

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Abstract

This thesis describes phytochemical investigations on the chemical constituents of two plants: Silene conoidea and Stocksia brahuica and resulted in the isolation and characterization of nine new natural products and a new derivative prepared synthetically. In addition to new constituents, 21 known compounds have also been isolated and characterized for the first time from these species. The new constituents isolated from Silene conoidea are conoidene (1),8(-L-rhamnopranosyl)-C-Dglucopyranosylidiosmetin (2),8(4-L-rhamnopyraosyl)-C--D-glucopyranosylapigenin (3) and from Stocksia brahuic are ethyl 3, 5-dihydroxy-4-methoxybenzoate (8), 2-hydroxy-3-methylbenzoic acid (9), diphenylacetic acid (10), brahol (22) and methyl -D-fructoside (23). A new synthetically prepared derivative is braholpentaacetate (22a). The new source coumpounds isolated from S. conoidea are -spinasterol (4), -spinasterolglucoiside (5), D-pinitol (6), sucrose (7) and from S. brahuica are 3, 4, 5-trihydroxhbenzoic acid (11), 3, 4, 5-trimethoxybenzoic acid (12), methyl 4-hydroxy-3, 5-dimethoxybenzoate (13), ethyl 3, 4, 5-trihydroxybenzoate (14), methyl 4-hydroxybenzoate (15), n-propyl 4-hydroxybenzoate (16), methyl p-hydroxycinnamate (17), brahene (18), 3-O-rutinosyl-3, 4, 5, 7-tetrahydroxyflavone (19), 7-hydroxy-6-methoxycoumarin (20), -tocopherol (21), ethyl -D-glucoside (24), sucrose (25), pimaric acid (26), isopimaric acid (27), stigmasterol (28), stigmasterolglucoside (29), -sitosterol (30) and -sitosterolglucoside (31). The structure elucidation of all compounds was carried out b using different spectroscopic techniques including 1H-NMR, 13C-NMR, DEPT, HMQC, HMBC, COSY-45, nOe, EI, CI, FD, -ve and +ve FABS, IR, UV etc.

Item Type:Thesis (PhD)
Uncontrolled Keywords:silene conoidea, stocksia brahuica, stocksia brahuica benth, silene conoidea linn
Subjects:Physical Sciences (f) > Chemistry(f2)
ID Code:745
Deposited By:Mr. Muhammad Asif
Deposited On:28 Sep 2006
Last Modified:04 Oct 2007 21:02

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