I= SPECTROSCOPIC AND CHEMICAL STUDIES ON THE CHEMICAL CONSTITUENTS OF SALVIA TRILOBA AND RELATED PLANT SPECIES
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Title of Thesis
SPECTROSCOPIC AND CHEMICAL STUDIES ON THE CHEMICAL CONSTITUENTS OF SALVIA TRILOBA AND RELATED PLANT SPECIES

Author(s)
Abdul Khaliq Dardass
Institute/University/Department Details
University of Karachi, Pakistan/Department of Chemistry
Session
1999
Subject
Chemistry
Number of Pages
167
Keywords (Extracted from title, table of contents and abstract of thesis)
salvia triloba, calamintha incana, lamiaceae (labiatae), terpeniods, flavonoids, betulinic acid, uvaol

Abstract
This thesis describes phytochemical investigations on the chemical onstituents of two plants: Salvia triloba and Calamintha incana both belong o the family Lamiaceae (Labiatae). Part :A: deals with the phytochemical investigation on Salvia triloba, whereas Part :B: of the thesis comprises studies on chemical constituents of Calamintha incana. The research work resulted isolatuion and characterization of four new natural products. In addition to four new constituents. Thirteen known components have been isolated, and characterized for the first time from these species, along with three known compound previously reported in literature.

The new constituents isolated from S. Triloba are Palestinol(1) (Fitoterapis)(1999) 70, 326) Akymman (2) and Akyordan (3), (Fitoterapis submitted) and from C. incana alquds (1). (Z. Naturforsch. (1999) 54b, 569).

The compound isolated for the first time from S. triloba included betulinic acid (4), uvaol (5) 5-hydroxy-7,4-dimethoxyflavone (7), 5-hydroxy-6,7,4-trimethoxyflavone (8) (x-spinasterol (9) and from C. incana are 5,7-dihydroxy-6,4-dimethoxyflavone (2), 3.5-dihydroxy-7,4-dimethoxyflavone (3) 3-o-rutinosyl-5,7,3, 4-tetrahydroxy (4), stigmasterol (5), stimasterol-3-O-glucoside (6).

The known compounds isolated and characterized from S. triloba include oleanolic acid (6) B-sitosterol (10) and B-stimasterol (11).

The structure elucidation of all the compounds were carried out by using modern spectroscopic techniques, including, 1-H-NMR, 13C-NMR, DEPT, HMGC, COSY-45, EIMS, CI, FD. FABs, -ve and +ve Amss IR and UV etc.

Download Full Thesis
1803.62 KB
S. No. Chapter Title of the Chapters Page Size (KB)
1 0 Contents
129.66 KB
2 1 Part- 1 :Studies on Chemical constituents of Salvia Triloba1 1
53.55 KB
  1.1 General Introduction 2
3 2 Terpeniods 5
280.93 KB
  2.1 Nomenclature of Terpenoids 8
  2.2 General Biosynthesis of Terpenoids 9
  2.3 Biosynthesis of Triterpenoids 12
  2.4 Biosynthesis of Diterpenoids 22
4 3 Botanical Description of salvia Triloba 33
73.12 KB
  3.1 Literature Review 34
5 4 Results and Discussion 40
437.13 KB
  4.1 Characterization of Palestinol 40
  4.2 Characterization of Akymman 44
  4.3 Characterization of Akyordan 47
  4.4 Characterization of Betulinic Acid 51
  4.5 Characterization of Uvaol 53
  4.6 Characterization of Oleanolic Acid 57
  4.7 Characterization of 5-Hydroxy-7 ,4 -dimethoxyflavone 60
  4.8 Characterization of 5-Hydroxy-7 ,4 -trimethoxyflavone 65
  4.9 Characterization of a-Spinasterol 70
  4.10 Characterization of B-Sitosterol 73
  4.11 Characterization of B- Sitosterol Glucol 75
6 5 Experimental 77
279.85 KB
  5.1 General Experimental Notes 77
  5.2 Salvia Triloba 79
  5.3 Eghyl Acetate Soluble Constituents of S. Triloba 81
  5.4 References 96
7 6 Part II : Studies on Chemical Constituents of Clamintha Incana. 103
297.4 KB
  1 Flavonoids 103
  1.1 Biosynthesis of Flavonoids 108
  1.2 Physiological Properties of Flavonoids 120
  1.3 Literature Review 124
8 7 Results and Discussions 129
271.63 KB
  7.1 Characterization of Genkwanin-4-O-rutionoside ( Alquds ) 129
  7.2 Characterization of 5 ,7 -Dihydroxy-6,4-dimethoxyflavone 136
  7.3 Characterization of 3 ,5 -Dihydroxy-7,4-dimethoxyflavone 138
  7.4 Characterization of 3-O-Rutinosyl-5 ,7,3 , 4-tetrahydroxyflavone 141
  7.5 Characterization of Stigmasterol 145
  7.6 Characterization of Stigmasterol-3-O-glucoside 148
9 7 Experimental 151
271.63 KB
  7.1 Material and Methods 151
  7.2 Extraction and Isolation 151
10 8 Experimental 160
196 KB
  8.1 List of Publications 167