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STUDIES ON THE CHEMICAL CONSTITUENTS OF CADABA FARINOSA

Amber, Aziz-Ur-Rehman (1990) STUDIES ON THE CHEMICAL CONSTITUENTS OF CADABA FARINOSA. PhD thesis, University of Karachi, Karachi.

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Abstract

The “Studies on the chemical constituents of cadaba farinose forssk (synfruticosa, L. Druce.)” have led to the isolation of three novel spermidine alkaloids, one novel sesquiterpenoid, alongwith another spermidine alkaloid, pprisine and an aromatic acid, a,b-Dihydro ferulic acid. The last two mpoounds were isolated from this genus for the first time. The thesis also includes the total synthesis of a spermidine alkaloid, iabicine methyl ether. The three novel spermidine alkaloids named as cadabicine, cadibicine methyl ether and cadabicine diaceteate, have the same skeletal system. They are rocyclic alkloids containing hydroxylated, methoxylated or acetylated, trans ferulic acid residues which are linked to each other through oxygen bridge and spermidine, through amide bonds. These type of compounds may exist in two to isomeric forms with respect to spermidine moiety. The spectral data londing, UV, IR, 1H-NMR cannot decide the exact structure of such ers but their structure can be confirmed by X-rays crystallography or ugh mass spectral fragmentation pattern. The structure of cadabicine was confirmed through X-ray analysis. The structure of cadabicine methyl ether was elucidated by mass spectral sentation and comparison with cadabicine and inally confirmed by its total thesis. Similarly the structure of cadabicine diacetate was confirmed through spectral fragmentation pattern, other modern spectroscopic methods and it comparison with cadabicine and its diacetyl derivative. Their structures live below.

Item Type:Thesis (PhD)
Uncontrolled Keywords:cadaba farinosa, (synfruticosa, l. druce.), a-b-dihydro ferulic acid, spermidine alkaloid, cadabicine methyl ether, capparisine, cadabicilone, cadabicine diacetate
Subjects:Physical Sciences (f) > Chemistry(f2)
ID Code:710
Deposited By:Mr. Muhammad Asif
Deposited On:27 Sep 2006
Last Modified:04 Oct 2007 21:02

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