I= STUDIES ON THE CHEMICAL CONSTITUENTS OF STOKEYIA INDICA, ERVATAMIA CORONARIA AND HAPLOPHYLLUM SPECIES
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Title of Thesis
STUDIES ON THE CHEMICAL CONSTITUENTS OF STOKEYIA INDICA, ERVATAMIA CORONARIA AND HAPLOPHYLLUM SPECIES

Author(s)
Zahir Shah
Institute/University/Department Details
University of Karachi/H.E.J Research Institute of Chemistry
Session
1990
Subject
Chemistry
Number of Pages
221
Keywords (Extracted from title, table of contents and abstract of thesis)
stokeyia indica, ervatamia coronaria, haplophyllum, lignans, haplophyllum buxbaumii

Abstract
The thesis is divided into four parts. Part-A describes studies on the chemical constituents of Haplophyllum burbaumii. Investigation on the stem bark of H. buxbaumii has led to the isolation of five new ligan glucosides:

Part-B describes studies on the chemical constituents of Stokeyia indica. Investigation on S. judica has led to the isolation and structure elucidation of a novel linear metabolite (stokerine, 11), besides loliolide (12) and fucosterol (13) isolated for the first time from this brown alga.

Part-C describes studies on the chemical constituents of Ervatamia coronaria. Investigation on the twigs of E. coronaria has led to the isolation of the following compounds.

Part-D of the thesis contains the Experimental section, and is followed b the References.

Modern spectroscopic techniques including 2D NMR experiments (2D-J-resolved, COSY-45, NOESY, NOE, HeteroCOSY, SECSY) were employed and chemical transformations were carried out to establish the structures of the above mentioned compounds. The stereochemistry was established by extensive NOE difference measurements.

Temperature dependent 1H-NMR studies were carried out to gain insight into the conformational equilibria existing in compounds (3), (5) and (10).

Download Full Thesis
1533.15 KB
S. No. Chapter Title of the Chapters Page Size (KB)
1 0 Contents
114.17 KB
2 1 Lignans 15
49.86 KB
  1.1 Introduction 15
  1.2 Classification 18
  1.3 Biosynthesis 26
3 2 Isolation And Structure Elucidation Of Lignans From Haplophyllum Species 39
208.99 KB
  2.1 Introduction 39
  2.2 Results And Discussion 39
4 3 Isolation And Structure Elucidation Of Compounds From Stokeyia Indica 113
149.66 KB
  3.1 Introduction 113
  3.2 Results And Discussion 116
5 4 Isolation And Structure Elucidation Of Compounds From Ervatamia Coronaria 137
662.02 KB
  4.1 Introduction 137
  4.2 Results And Discussion 139
6 5 Experimental 169
193.23 KB
  5.1 General Experimental Procedure 169
  5.2 Lignans From Haplophyllum Buxbaumii 171
  5.3 Compounds From Stokeyia Indica 189
  5.4 Compounds From Ervatamia Coronaria 193
7 6 References 205
275.24 KB