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STUDIES ON THE CHEMICAL CONSTITUENTS OF STOKEYIA INDICA, ERVATAMIA CORONARIA AND HAPLOPHYLLUM SPECIES

Shah, Zahir (1990) STUDIES ON THE CHEMICAL CONSTITUENTS OF STOKEYIA INDICA, ERVATAMIA CORONARIA AND HAPLOPHYLLUM SPECIES. PhD thesis, University of Karachi, Karachi.

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Abstract

The thesis is divided into four parts. Part-A describes studies on the chemical constituents of Haplophyllum burbaumii. Investigation on the stem bark of H. buxbaumii has led to the isolation of five new ligan glucosides: Part-B describes studies on the chemical constituents of Stokeyia indica. Investigation on S. judica has led to the isolation and structure elucidation of a novel linear metabolite (stokerine, 11), besides loliolide (12) and fucosterol (13) isolated for the first time from this brown alga. Part-C describes studies on the chemical constituents of Ervatamia coronaria. Investigation on the twigs of E. coronaria has led to the isolation of the following compounds. Part-D of the thesis contains the Experimental section, and is followed b the References. Modern spectroscopic techniques including 2D NMR experiments (2D-J-resolved, COSY-45, NOESY, NOE, HeteroCOSY, SECSY) were employed and chemical transformations were carried out to establish the structures of the above mentioned compounds. The stereochemistry was established by extensive NOE difference measurements. Temperature dependent 1H-NMR studies were carried out to gain insight into the conformational equilibria existing in compounds (3), (5) and (10).

Item Type:Thesis (PhD)
Uncontrolled Keywords:stokeyia indica, ervatamia coronaria, haplophyllum, lignans, haplophyllum buxbaumii.
Subjects:Physical Sciences (f) > Chemistry(f2)
ID Code:697
Deposited By:Mr. Muhammad Asif
Deposited On:27 Sep 2006
Last Modified:04 Oct 2007 21:02

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