I= STUDIES ON THE TRITERPENOIDAL CONSTITUENTS OF NEPETAHINDOSTANA (ROTH) HAINES AND THE ROOTS OF SYMPHYTUM OFFICINALEL
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Title of Thesis
STUDIES ON THE TRITERPENOIDAL CONSTITUENTS OF NEPETAHINDOSTANA (ROTH) HAINES AND THE ROOTS OF SYMPHYTUM OFFICINALEL

Author(s)
Faryal Vali Mohammad
Institute/University/Department Details
University of Karachi./H.E.J. Research Institute of Chemistry
Session
1992
Subject
Chemistry
Number of Pages
187
Keywords (Extracted from title, table of contents and abstract of thesis)
nepetahindostana (roth) haines, symphytum officinalel, genus nepeta, antibacterial activity, triterpenoids, saponins

Abstract
The present thesis is composed of two parts. The Part-I describes the studies on the chemical constituents of Nepeta hindostana Roth Haines, (syn. Glechoma erecta Buch, Gelchoma hindostana Roth, N. ruderalis Hamilt, N. calaminthoides Royle ex Benth.) belonging to the isolation and structural elucidation of four new triterpenoids which were named as nepehinol (1) nepetidone (2) nepehinal (4) and nepedinol (5). These compounds belongs to the lupine series of triterpenoids. Nepehinol (1) was isolated from the column chromatography of the hexane extract of Nepeta hindostana, while the rest of the compounds were isolated form the ethanolic extract of this plant.

Download Full Thesis
1124.21 KB
S. No. Chapter Title of the Chapters Page Size (KB)
1 0 Contents/ Summary
95 KB
2 1 General Introduction 10
70.23 KB
3 2 Intruduction 17
329.58 KB
  2.1 Botanical Description Of Nepeta Hindostana 18
  2.2 Medicinal Importance Of The Genus Nepeta 18
  2.3 Pharmacology Of Nepeta Hindostana 21
  2.4 Microbiology Of Nepeta Hindostana 23
  2.5 Literature Survey Of The Genus Nepeta 23
  2.6 Biosynthesis Of Triterpenoids 42
4 3 Present Work 71
143.48 KB
  3.1 The Antibacterial Activity Of Nepeta Hinodstana 71
  3.2 Isolation And Structure Elucidation Of Nepehinol (1) 71
  3.3 Isolation And Structure Elucidation Of Nepentidone (2) 72
  3.4 Isolation And Structure Elucidation Of Nepehinal (4) 81
  3.5 Isolation And Structure Elucidation Of Nepehinol (5) 86
5 4 Experimental 91
99.1 KB
  4.1 General Instrumentation 91
  4.2 Plant Material 95
  4.3 Extraction And Isolation Of Triterpenoids 95
  4.4 Characterization Of Nepehinol (1) 96
  4.5 Characterization Of Nepetidone (2) 99
  4.6 Characterization Of Nepehinal (4) 101
  4.7 Characterization Of Nepehinol (5) 103
6 5 References 106
86.46 KB
7 6 Introduction 117
96.91 KB
  6.1 Saponins 117
  6.2 Biological Activity 118
  6.3 Medicinal Uses Of Saponins 119
  6.4 Biological Inmprtance Of Symphytum Officinale L 126
8 7 Present Work 129
252.45 KB
  7.1 Isolation And Structure Elucidation Of Saponin A (7) 129
  7.2 Isolation And Structure Elucidation Of Saponin B (8) 138
  7.3 Isolation And Structure Elucidation Of Saponin C (9) 146
  7.4 Isolation And Structure Elucidation Of Saponin D (10) 155
9 8 Experimental 165
96.45 KB
  8.1 Plant Material 165
  8.2 Extraction And Isolation Of Saponins 165
  8.3 Characterization Of Saponin A (7) 166
  8.3 Characterization Of Saponin B (8) 169
  8.3 Characterization Of Saponin C (9) 171
  8.3 Characterization Of Saponin D (10) 173
10 9 References 177
87.12 KB
  9.1 List of Publications 185