I= PHYTOCHEMICAL INVESTIGATIONS OF THE CHEMICAL CONSTITUENTS OF BUXUS SPECIES AND SYNTHESES WITH METAL COMPLEXES
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Title of Thesis
PHYTOCHEMICAL INVESTIGATIONS OF THE CHEMICAL CONSTITUENTS OF BUXUS SPECIES AND SYNTHESES WITH METAL COMPLEXES
Author(s)
Syed Erfan Asif
Institute/University/Department Details
University Of Karachi, Pakistan./H.E.J. Research Institute Of Chemistry
Session
1993
Subject
Chemistry
Number of Pages
225.
Keywords (Extracted from title, table of contents and abstract of thesis)
metal complexes, buxus species, alkaloids, buxus sempervirens, pyrazole, phytochemical research, b. papillosa, bisnaphthyl acetylene, cyclopentadienylbis carbonyl cobalt

Abstract
This thesis presents phytochemical research on two medicinal plants. Studies on the leaves of Buxus sempervirens and roots of B. papillosa have led to the isolation and characterization of six new steroidal bases. In addition, eight more compounds have also been reported for the first time fromboth these plants. Some spectral generalizations made for Buxus alkaloids based on a comparative literature is included.

The thesis further presents some work on syntheses with metal complexes. The reaction of bisnaphthyl acetylene with cyclopentadienylbis carbonyl cobalt has resulted in the formation of three new products. Besides, some reactions were done with rhodium complex to develop four new six-membered ring systems. A few Pd-Cu catalyzed reactions of terminal acetylenes with different aryl halides are also presented in this thesis.
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S. No. Chapter Title of the Chapters Page Size (KB)
1 0 Contents/ Summary
105.24 KB
2 1 General Introduction 9
35.23 KB
3 2 Introduction 13
413.05 KB
  2.1 alkaloids 14
4 3 Results and Discussion 69
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  3.1 New Alkaloids from the leaves of Buxus semperviens 70
  3.2 Known alkaloids unreported from Buxus sempervirens 90
  3.3 New alkaloids from the roots of Buxus papillosa 97
  3.4 Unreported alkaloids from Buxus papillosa 112
5 4 Experimental 126
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  4.1 General Experimental conditions 127
  4.2 Plant material Buxus Sempervirens 129
  4.3 Extraction and purification 129
  4.4 Compounds from the leaves of Buxus smpervirens 132
6 5 References 148
115.99 KB
7 6 Syntheses with metal complexes 161
271.03 KB
  6.1 reaction of – Cyclopentadienyldicarbonycobalt with Bis - naphthylacetylene 162
  6.2 The diyne reactions of 1 ,8 -bis ( phenylethynyl ) naphthalene With transition metal complexes to from new compounds 169
  6.3 Introduction 169
  6.4 Reaction of the new transition metal complex with alkynes 169
  6.5 Palladium – copper catalysed reactions of terminal acetylenes With different arylhalides 176
  6.6 Introduction 176
  6.7 Reaction of N-(4-Pentenyl) benzimidazole with 2-Bromo-1, 6-methano [10] annulene 176
  6.8 Reaction of N-(4-Pentenyl) pyrrole with 2-Bromo-1, 6-methano [10] annulene 178
  6.9 Reaction of 1-Bromonaphthalene with trimethyl Silylacetylene 180
  6.10 Reaction of 2-methyl 3-butyne-2-ol with 1 Bromonaphthalene 182
  6.11 Hydrolysis of 1-(3-dimethyl-1’ –butyne-3-ol) naphthalene 184
  6.12 Reaction of 2-bromo-1 ,6 -methano [10] annulene with 1-ethynylnaphthalene 186
  6.13 Some miscellaneous Reactions 189
  6.14 Reaction of imidazole with 4-iodobutyronitrile 189
  6.15 Reaction of pyrazole with 4-lodobutyronitrile 190
  6.16 Reaction between pyrazole and 5-lodo-1-pentyne 190
  6.17 Reaction of pyrrole with 5-lodo-1-pentyne 193
  6.18 Synthesis of Rhodium-complex (14) 195
  6.19 Synthesis of 1 ,8 -Bis-(phenyl ethynyl ) naphthalene (13) 195
  6.20 Synthesis of 1 ,8 -diiodonaphthalene (39) 197
8 7 Experimental 199
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  7.1 General Experimental Conditions 200
  7.2 Cyclopnetadienyl ( tetranaphthyl cyclobutadiene ) cobalt (8) 202
  7.3 Tetranaphthyl cyclobutadiene (9) 203
  7.4 Cyclopentadienyl ( Tetranaphthyl cyclobutadiene ) cobalt (10) 203
  7.5 7 ,9 -( Bisphenyl )-8-(1 naphthyl )-9-( trimethylsilyl ) fluranthen (15a) 204
  7.6 7 ,10 -( Bisphenyl )-8-(1 naphthyl )-9-(2’-annulenyl) fluranthen (15b) 205
  7.7 7,8,10 ( Triphenyl )-9-(2’- annulenyl ) fluoranthen (15c) 206
  7.8 7,8,10 ( Triphenyl )-9-(N ,N - biphenylamine ) fluoranthen (15d) 207
  7.9 2-(4-pentenyl)-5(N- pyrrole )-1 ,6 -methano [10] annulene (20) 208
  7.10 2-(4-pentenyl)-5(N- benzimidazole )-1 ,6 -methano [10] annulene (20) 209
  7.11 1-( trimethylsilylethynyl ) naphthalene (25) 211
  7.12 1-(3,-di-methyl-1, -butyne-3,-ol) naphthalene (27) 212
  7.13 1-Ethynyl-naphthalene (28) 213
  7.14 2(1-naphthyl ethnyl )-1 ,6 -methano [10] annulene (29) 213
  7.15 1 ,8 -( bisphenylethynyl ) naphthalene (13) 215
  7.16 Rhodium-complex (14) 215
  7.17 0 ,8 -Diiodonaphthalene (39) 216
  7.18 N-(4-Butyronitrile) Pyrazole (34) 216
  7.19 N-(4-Butyronitrile) pyrazole (32) 217
  7.20 N-(4-Pentynyl) pyrazole (36) 218
  7.21 N-(4-Pentynyl) pyrrole (38) 219
9 8 References 221
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