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SYNTHESES AND CHARACTERIZATION OF TIN METAL COMPLEXES WITH PHTHALOYL AMINO ACIDS

Muhammad, Ashfaq (1998) SYNTHESES AND CHARACTERIZATION OF TIN METAL COMPLEXES WITH PHTHALOYL AMINO ACIDS. PhD thesis, Islamia University, Bahawalpur.

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Abstract

The synthesis, physical nature and spectroscopic characterization of several new phthaloyl mnino acids (ligands) have been carried out. Initially, series of two different types of complexes are produced i.e. A-type: Monomeric dibutyltin diphthaloyl-N-carboxylates with 2: 1 molar ratio of general formula [C6H4 (CO)2 NRCOO]2 SnBu2, B-type: Dimeric tetraorgano dibutyl distannoxane diphthaloyl-N-carboxylates with 1:1 molar ratio of general formula [{C6 H4 (CO)2 NRCOO-SnBU2}2O]2 where R = -CH2-, -C2H4, -C4H7, -C5H9-C2H3C6H5-C2H3C6H5OH. They are characterized by CHN analyzer, FTIR, 1H-, 13C-, 119Sn-multinuclear FTNMR and Mossbauer Spectrometer. Different methods, reported in the literature have been successfully applied for qualitative structural characterization of these compounds. The monomeric dibutyltin diphthaloyl-N-Carboxylates complexes behave as hexa-coordinate and possess trans octahedral geometry. The dimeric tetraorgano dibutyl distannoxane diphthaloyl carboxylate complexes have penta coordinate environment with a pair of exo-and endo-cyclic structure having fluxional behavior of organic moieties. The synthesis and spectroscopic characterization of sodium salts of phthaloyl amino acids have also been carried out. The series of triphenyl and tricyclohexyltin complexes with each of the sodium salts of phthaloyl amino acids are prepared and it characterized physically and spectroscopically by CHN analyzer, FTIR, 1H-, 13C-, 119Sn-multinuclear FTNMR and Mossbauer Spectrometer. The trioganotins with triphenyl moieties are assigned penta-coordinate environment with polymeric trigonal bipyramidal geometry in solid and tetrahedral structure in inert solvent while the complexes with tricyclohexyl moieties possess monomeric tetra hedral geometry in solid and in solution. Biological activity tests are carried out and it is found that most of the mono and dimeric compounds are biocidally active as well as the triorgano- tins show high biocidal activity against various bacteria and fungi ED50 tests of all the synthesized complexes are also conducted. Most of the mono and dimeric compounds as well as triorganotin complexes exhibit significant lethality to brine shrimp nauplii (larvae). When the solubility test is made, the ethanolic solution of some of the complexes show hydrophillic characteristic which is an improved step towards the bio-availability of organotin complexes in vitro and in vivo study.

Item Type:Thesis (PhD)
Uncontrolled Keywords:Tin Metal Complex, Phthaloyl mnino acids (ligands), A-Type Meric Complex, B-Type Dimeric Complexes, C-Type Triorganotin Complexes, Monomeric dibutyltin diphthaloyl-N-Carboxylates, Dimeric tetraorgano dibutyl distannoxane diphthaloyl-N-carboxylates
Subjects:Physical Sciences (f) > Chemistry(f2)
ID Code:677
Deposited By:Mr. Muhammad Asif
Deposited On:22 Sep 2006
Last Modified:04 Oct 2007 21:02

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