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| Pakistan Research Repository | Home |
Title of Thesis |
| Author(s) Irfan Baig |
| Institute/University/Department Details International Centre for Chemical Sciences University of Karachi/H.E.J. Research Institute of Chemistry |
| Session 2002 |
| Subject Chemistry |
| Number of Pages 232 |
| Keywords (Extracted from title, table of contents and abstract of thesis) ferula mongolica, mongolian medicinal plants, iris flavissima, glucosidase, sesquiterpenoid pyrano-benzophyran, sesquiterpenoid furo-benzopyrane, sesquiterpenoid furo-coumarin, sesquiterpenoid coumarin, sesquiterpenoid benzovl, sesquiterpene: guaiol |
Abstract Part A The phytochemical investigations on the air-dried roots of Ferula mongolica resulted in the isolation and characterization of six new (compound 1-6) and seven known compounds. The chemical structures of these compounds were determined by using different spectroscopic techniques. These compounds belong to various structural classes as described below: Sesquiterpenoid Pyrano-benzophyran Derivative: A new sesquiterpenoid pyrano-benzopyrane derivative, baigene A (1) has been isolated from the air-dried roots of F. mongolica. Sesquiterpenoid Furo-benzopyrane Derivatives: A new sesquitterpenoid furo-benzophyrane derivative, baigene B (2) and a known (2R*,3S*) baigene B (8) have also been isolated from the roots of F. mongolica. Sesquiterpenoid Furo-Coumarin Derivatives: Two new members f this class, baigene C (3) and 7’-methoxybaigene C (4) along with two known metabolites, (2R*,3S*) baigene C (9) and mongolin C (11) hve also ben isolated from this plant. Sesquiterpenoid Coumarin Drivative: A new sesquiterpenoid coumarin, mongolin A (5) has also been isolated from the air-dried roots of F. mongolica. Sesquiterpenoid Benzovl Derivatives: A new compound mongolin B (6), a synthetically known compound 4’-methoxy-dshamirone (7) along with two known sesquiterpenoid benzoyl derivatives, dshamirone (10) and mongolin D (12) have een isolated from the air-dried roots of F. mongolica. Sesquiterpene: Guaiol (13) is a know sesquterpene, which was also isolated for the first time from F. Mongolica. Part B Phytochemical investigations on the air-dried roots of another Mongolian medicinal plant, Iris flavissima have resulted in the isolation and characterization of a new isoflavone, sufiol (14) along with nine known isoflavones, iriskashmirianin (15), irisflorentin (16), 3’-O-methyliriskumaonin (17), 4’-methoxyirilone (18), iriskumaonin (19), irigenin (20), iristectorigenin A (21), dichotomitin (22) and iristectorigenin B (23). A well known triterpene, ursolic acid (24), was also isolatd for the first time from this plant. Isoflavones: A new isoflavone sufiol (14) and nine known isoflavones 15-23 have been isolated for the first time from the air-dried roots of I. flavissima. Triterpene: A known triterpene ursolic acid was isolated from the roots of I. flavissima for the first time. Part C This part of the thesis describes the results of some biological assays on newly isolated compounds. Some of these compounds were found to be active against the enzyme a-glucosidaase, whereas some others exhibited significant anti-inflammatory activity. Part C is therefore further divided in to two parts. Part C (I); This part contains the detail of the enzyme inhibitory activities of the compounds isolated from the roots of F. mongolica and I. flavissima. The inhibition of the a-glucosidase is an effective mean of controlling the hyperglycaemia and late complications associated with type II diabetes, Compounds 1-4, 6-8 and 10-12 exhibited significant enzyme inhibitory activity, while compounds 15, 17, 21 and 23 wwere found to be moderately active. Part C (II): The reported antioxidant and associated anti-inflammatory activities of flavonoids derivatives of palnt origin, guided that the isoflavones isolated from the roots of I. flavissima were also subjected to anti-inflammatory activity assay. Some of these compounds exhibited significant anti-inflammatory activities. Part-C-II thus describes the details of the anti-inflammatory assays of these compounds. |
| Download Full Thesis |  2654.67 KB |
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| S. No. | Chapter | Title of the Chapters | Page | Size (KB) |
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| 1 | 0 | Contents | 80.99 KB |
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| 2 | 1 | Summary | 1 | 73.61 KB |
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| 3 | 2 | General Introduction | 8 | 55.29 KB |
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| 4 | 3 | Part A (Phytochemical Investigation on Ferula mongolica) | 12 | 1898.67 KB |
| 3.1 | Introduction | 13 | ||
| 3.2 | Results and Discussion | 71 | ||
| 3.3 | Experimental Section | 138 | ||
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| 5 | 4 | Part B (Phytochemical Investigation on Iris flavissima) | 153 | 421.07 KB |
| 4.1 | Introduction | 154 | ||
| 4.2 | Results and Discussion | 167 | ||
| 4.3 | Experimental Section | 184 | ||
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| 6 | 5 | Part C Biological Activity | 196 | 395.33 KB |
| 5.1 | Part C-I a-Glucosidase Inhibition | 197 | ||
| 5.2 | Part C-II Anti-Inflammatory Activity | 206 | ||
| 5.3 | References | 211 | ||
| 5.4 | List of Publications | 232 | ||
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