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PHYTOCHEMICAL STUDIES ON FERULA MONGOLICA AND OTHER MONGOLIAN MEDICINAL PLANTS

Baig, Irfan (2002) PHYTOCHEMICAL STUDIES ON FERULA MONGOLICA AND OTHER MONGOLIAN MEDICINAL PLANTS. PhD thesis, University of Karachi, Karachi.

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Abstract

This research work described in this Ph.D. thesis is divided in to three parts. Part A deals with phytochemical investigations on the air-dried roots of a Mongolan medicinal plant, Ferula monolica Seud, whereas Part B describes the chemistry of the rhizomes of an another Mongolian plant Iris flavissima Pall, Part C of the thesis contains the details of bioactivities of the compounds isolated from the above mentioned Mongolian plants and it is further divided into two sub-arts, Part C-1 explains the inhibitory activity of these compounds against the enzyme a-glucosidase, whereas Part C-II deals with the anti-inflammatory activity of the isoflavones isolated from I. flavissima. Part A The phytochemical investigations on the air-dried roots of Ferula mongolica resulted in the isolation and characterization of six new (compound 1-6) and seven known compounds. The chemical structures of these compounds were determined by using different spectroscopic techniques. These compounds belong to various structural classes as described below: Sesquiterpenoid Pyrano-benzophyran Derivative: A new sesquiterpenoid pyrano-benzopyrane derivative, baigene A (1) has been isolated from the air-dried roots of F. mongolica. Sesquiterpenoid Furo-benzopyrane Derivatives: A new sesquitterpenoid furo-benzophyrane derivative, baigene B (2) and a known (2R*,3S*) baigene B (8) have also been isolated from the roots of F. mongolica. Sesquiterpenoid Furo-Coumarin Derivatives: Two new members f this class, baigene C (3) and 7’-methoxybaigene C (4) along with two known metabolites, (2R*,3S*) baigene C (9) and mongolin C (11) hve also ben isolated from this plant. Sesquiterpenoid Coumarin Drivative: A new sesquiterpenoid coumarin, mongolin A (5) has also been isolated from the air-dried roots of F. mongolica. Sesquiterpenoid Benzovl Derivatives: A new compound mongolin B (6), a synthetically known compound 4’-methoxy-dshamirone (7) along with two known sesquiterpenoid benzoyl derivatives, dshamirone (10) and mongolin D (12) have een isolated from the air-dried roots of F. mongolica. Sesquiterpene: Guaiol (13) is a know sesquterpene, which was also isolated for the first time from F. Mongolica. Part B Phytochemical investigations on the air-dried roots of another Mongolian medicinal plant, Iris flavissima have resulted in the isolation and characterization of a new isoflavone, sufiol (14) along with nine known isoflavones, iriskashmirianin (15), irisflorentin (16), 3’-O-methyliriskumaonin (17), 4’-methoxyirilone (18), iriskumaonin (19), irigenin (20), iristectorigenin A (21), dichotomitin (22) and iristectorigenin B (23). A well known triterpene, ursolic acid (24), was also isolatd for the first time from this plant. Isoflavones: A new isoflavone sufiol (14) and nine known isoflavones 15-23 have been isolated for the first time from the air-dried roots of I. flavissima. Triterpene: A known triterpene ursolic acid was isolated from the roots of I. flavissima for the first time. Part C This part of the thesis describes the results of some biological assays on newly isolated compounds. Some of these compounds were found to be active against the enzyme a-glucosidaase, whereas some others exhibited significant anti-inflammatory activity. Part C is therefore further divided in to two parts. Part C (I); This part contains the detail of the enzyme inhibitory activities of the compounds isolated from the roots of F. mongolica and I. flavissima. The inhibition of the a-glucosidase is an effective mean of controlling the hyperglycaemia and late complications associated with type II diabetes, Compounds 1-4, 6-8 and 10-12 exhibited significant enzyme inhibitory activity, while compounds 15, 17, 21 and 23 wwere found to be moderately active. Part C (II): The reported antioxidant and associated anti-inflammatory activities of flavonoids derivatives of palnt origin, guided that the isoflavones isolated from the roots of I. flavissima were also subjected to anti-inflammatory activity assay. Some of these compounds exhibited significant anti-inflammatory activities. Part-C-II thus describes the details of the anti-inflammatory assays of these compounds.

Item Type:Thesis (PhD)
Uncontrolled Keywords:ferula mongolica, mongolian medicinal plants, iris flavissima, glucosidase, sesquiterpenoid pyrano-benzophyran, sesquiterpenoid furo-benzopyrane, sesquiterpenoid furo-coumarin, sesquiterpenoid coumarin, sesquiterpenoid benzovl, sesquiterpene: guaiol
Subjects:Physical Sciences (f) > Chemistry(f2)
ID Code:662
Deposited By:Mr. Muhammad Asif
Deposited On:14 Sep 2006
Last Modified:04 Oct 2007 21:02

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