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Title of Thesis

Effects Of Different Preparations Of Nigella Sativa (ns) On Glucose And Lipid Metabolism In Type II Diabetic Patients

Author(s)

Ahmad Bilal

Institute/University/Department Details
Department of Food Technology Faculty of Crop and Food Sciences, Pir Mehr Ali Shah Arid Agriculture University, Rawalpindi
Session
2008
Subject
Food Technology
Number of Pages
314
Keywords (Extracted from title, table of contents and abstract of thesis)
Placebo, Investigate, Cholesterol, Effects, Nigella, Sativa, Metabolism, Lipid, Observed, Diabetic, Patients

Abstract
The basic aim of this placebo control study was to investigate the effects of three different preparations of Nigella sativa especially on glucose and lipid metabolism in type 2 diabetes mellitus (DM2) patients (group-A); however normal individuals (group- B) was also studied. Both groups were treated with N. sativa Seed Powder (NsP), N. sativa Aqueous Extract (NsE) and N. sativa Oil (NsO), in addition to a placebo in phases 1, 2 and 3 respectively. Each phase was of 80 days (40 days of treatment with N. sativa preparation followed by 40 days of placebo administration). Levels of 0 day were taken as base line (concurrent control) in each phase. Fasting blood levels of glucose, insulin, total cholesterol (TC), LDL & HDL cholesterols, triglycerides (TG), total leukocyte & platelet counts, hepatic profile and blood urea were determined in subjects of both groups on 0, 40 and 80th day of each phase of the study. In phase-1 a highly significant fall in fasting blood glucose, TC, LDL cholesterol and TG while an increase in insulin and HDL was observed in group-A after treatment with NsP as compared to concurrent control. These levels significantly reversed at the end of placebo except the HDL cholesterol. Almost similar results were obtained in subjects of group-B. In phase-2 although a decrease in glucose and increase in insulin levels was observed in group-A after treatment with NsE; which reversed after the placebo yet the changes were not significant. However a significant fall was observed in TC and TG levels of diabetics after NsE treatment; which reversed after the placebo significantly in TG but insignificantly in TC. In group B, results regarding glucose and insulin levels were similar to that of group-A of this phase. Concerning lipid profile, a significant fall in TG and insignificant decrease in TC and LDL cholesterol was observed after NsE treatment. The changes reversed after the placebo, significantly in TG and LDL cholesterol but insignificantly in TC. In phase-3, a significant fall in fasting blood glucose and a rise in insulin levels was observed in group-A after treatment with NsO as compared to concurrent control levels. A significant decrease in LDL & increase in HDL was observed while TC remained statistically unchanged; however a significant increase was also recorded in TG after NsO treatment. LDL and TG levels reversed significantly, while no significant change was observed in HDL and TC levels after the placebo. Subjects of group-B behaved similar to group-A, as for glucose and insulin are concerned. Regarding lipids, a decrease in LDL cholesterol (significant) and TC (insignificant) while increase in HDL cholesterol and TG (insignificant) was observed in group-B after the use of NsO. LDL and TC increased significantly after the placebo while no significant change was recorded in HDL cholesterol and TG. Total leukocyte and platelet counts remained statistically unchanged in both groups A and B, when treated with NsP, NsE, NsO or administered with placeboes in phases 1, 2 and 3 respectively as compared to their base line levels Similarly no unpleasant effect of any of the N. sativa preparation was observed regarding hepatic profile, blood urea and the subjective feelings of the diabetic and normal individuals. In the light of foregoing facts it can safely be concluded that all preparations of N. sativa had some or more antidiabetic effect. However keeping in view the overall performance, NsP was found more effective. Further large scale human studies with different dose schedules of NsP are recommended.
 

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2,437 KB
S. No. Chapter Title of the Chapters Page Size (KB)
1 0 CONTENTS
 

 

v
41 KB
2 1 INTRODUCTION

 

3
32 KB
3 2 REVIEW OF LITERATURE

2.1 Diabetes Mellitus
2.2 Black Seed (NIGELLA SATIVA)
2.3 Effects of NIGELLA SATIVA Related To Diabeties
2.4 Other Effects Of NIGELLA SATIVA

8
109 KB
4 3 MATERIAL AND METHODS

3.1 Experimental Design
3.2 Selection Criteria For Type 2 Diabetic Patients
3.3 Selection Criteria For Normal Individuals
3.4 Approval For The Selection Of Patients In Hospitals
3.5 Blood Glucose Screening Test
3.6 Registration Consent And Briefing
3.7 Blood Samples And Analysis
3.8 Preparations Of NIGELLA SATIVA AND PLACEBO
3.9 Dietary Profile of The Subjects
3.10 Activity/exercise Level Of The Subjects
3.11 Stress Status Of The Subjects
3.12 Diabetic Complications/ Subjective Feelings
3.13 Data Collection
3.14 Statistical Analysis
3.15 Figures And Graphics

28
64 KB
5 4 RESULTS AND DISCUSSION

 

41
1,343 KB
6 5 SUMMARY, CONCLUSIONS AND RECOMMENDATIONS

 

229
39 KB
7 6 LITERATURE CITED AND APPENDICES

 

236
745 KB