I= CONDENSED HETEROCYCLICS FROM AMINOAZOLES
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Title of Thesis
CONDENSED HETEROCYCLICS FROM AMINOAZOLES
Author(s)
Najma Perveen
Institute/University/Department Details
Islamia University Bahawalpur/Department of Chemistry
Session
1996
Subject
Chemistry
Number of Pages
368
Keywords (Extracted from title, table of contents and abstract of thesis)
aminoazoles, antimicrobial activity, pyrazolo [3,4-b] pyridines, pyrazolo [1,5-a] pyrimidine, triazolo [1,5-a] pyrimidines, aminopyrazoles, amino triazoles, 5-amino-3-methyl-1-phenyl pyrazole

Abstract
A method for the preparation of pyrazolo [3,4-b] pyridines, pyrazolo [1,5-a] pyrimidine and triazolo [1,5-a] pyrimidines from aminopyrazoles and amino triazoles was developed. 5-Amino-3-methyl-1-phenyl pyrazole when reacted with benzaldehyde give the Schiff base which on reaction with acetophenone gives the corresponding pyrazolo [3,4-b] pyrimidines (i). The reaction of 3-amino-4-cyanopyrazole under similar conditions gave nitrogen bridgehead [1,5-a] in the form of pyrazolo [1,5-a] pyrimidines (ii) while 3-amino-triazole and 3-amino-5-phenyl-triazole also undergo cycliation to give the condensed systems, prazolo [1,5-a] pyrimidines (ii) and triazolo [1,5-a] pyrimidines (iii) in good yields. II and III were isolated as their dihydroproducts. The mechanism for the formation of these products is also proposed. The reaction products were characterized through their IR, PMR and mass spectra or elemental analysis. The products obtained from these reactions were also tested for antibacterial activity.

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S. No. Chapter Title of the Chapters Page Size (KB)
1 0 Contents
86.2 KB
2 1 Introduction 1
682.28 KB
3 2 Experimental 81
997.09 KB
4 3 Objective 187
546.12 KB
5 4 Reasoning for [1,5-A] Structure 253
27.17 KB
6 5 Evidences for Proposed Mechanisms 256
167.61 KB
7 6 Mass Spectrum 276
637.84 KB
8 7 Antimicrobial Activity 337
106.34 KB
9 8 Conclusion 349
29.4 KB
10 9 Bibliography 352
128.04 KB