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CONDENSED HETEROCYCLICS FROM AMINOAZOLES

Perveen, Najma (1996) CONDENSED HETEROCYCLICS FROM AMINOAZOLES. PhD thesis, Islamia University, Bahawalpur.

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Abstract

A method for the preparation of pyrazolo [3,4-b] pyridines, pyrazolo [1,5-a] pyrimidine and triazolo [1,5-a] pyrimidines from aminopyrazoles and amino triazoles was developed. 5-Amino-3-methyl-1-phenyl pyrazole when reacted with benzaldehyde give the Schiff base which on reaction with acetophenone gives the corresponding pyrazolo [3,4-b] pyrimidines (i). The reaction of 3-amino-4-cyanopyrazole under similar conditions gave nitrogen bridgehead [1,5-a] in the form of pyrazolo [1,5-a] pyrimidines (ii) while 3-amino-triazole and 3-amino-5-phenyl-triazole also undergo cycliation to give the condensed systems, prazolo [1,5-a] pyrimidines (ii) and triazolo [1,5-a] pyrimidines (iii) in good yields. II and III were isolated as their dihydroproducts. The mechanism for the formation of these products is also proposed. The reaction products were characterized through their IR, PMR and mass spectra or elemental analysis. The products obtained from these reactions were also tested for antibacterial activity.

Item Type:Thesis (PhD)
Uncontrolled Keywords:aminoazoles, antimicrobial activity, pyrazolo [3,4-b] pyridines, pyrazolo [1,5-a] pyrimidine, triazolo [1,5-a] pyrimidines, aminopyrazoles, amino triazoles, 5-amino-3-methyl-1-phenyl pyrazole
Subjects:Physical Sciences (f) > Chemistry(f2)
ID Code:603
Deposited By:Mr. Muhammad Asif
Deposited On:09 Sep 2006
Last Modified:04 Oct 2007 21:01

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