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Title of Thesis  
ISOLATION AND STRUCTURAL ELUCIDATION OF CHEMICAL CONSTITUENTS FROM FUMARIA INDICA, FERULA OOPODA AND WITHANIA SOMNIFERA  
Author(s)  
SHAKIL AHMED  
Institute/University/Department Details  
University Of Karachi, Karachi / Research Institute Of Chemistry  
Status (Published/ Not Published/ In Press etc)  
Published  
Date of Publishing  
1998  
Subject  
Education  
Number of Pages  
221  
   
Keywords (Extracted from title, table of contents and abstract of thesis)  
Fumaria indica, Ferula oopoda , Withania somnifera, Alkaloids, Heterocyclic alkaloids, Isoquinoline alkaloids, Tetrahydroisoquinoline alkaloids, Biosynthesis of Isoquinoline Alkaloids, Pavine and Isopavine, Aporphine Alkaloids, Protoberberine Alkaloids, Protopine Alkaloids, Phthalideisoquinoline Alkaloids, Secophthalideisoquinoline Alkaloids, Fumaileal (144), Fumaileate (149), Papraline (143), 9, 10 Methylenedioxy karachine (255), Vanillin (142), Cryptopine (61), (+) B Hydrastine (232), Corydaldine (147), Withanolides, Quresimine, Withaferine A, 2,3 Dihydrowithaferine A, Feraileate, Guaianolide, Grilactone, Isolation, Structure elucidation, COSY 450, HOHAHA, HMBC, HMQC,  

 

 
Abstract  

The thesis presents the isolation and structure elucidation of various classes of natural products which were isolated from three medicinal plants of Pakistan, i.e. Fumaria indica, Withania somnifera and Ferula oopoda. The structure of the compounds were determined on the basis of sophisticated spectroscopic techniques including one and two dimensional NMR spectroscopic experiments such as COSY 45o, HOHAHA, HMBC, HMQC etc. Phytochemical investigations on Fumaria indica have led to the isolation of four new components i.e. papraline (143), 4,5 dimethoxy 2 hydroxybenzaldehyde (144), fumaileate (149) and 9,10 methylenedioxy karachine (255) along with the four known isoquinoline alkaloids, 4 hydroxy 3 methoxybenzaldehyde (142), cryptopine (61), (+) B hydroastine (232) and corydaldine (147). The next section of the thesis describes the chemical constituents of Withania somnifera and includes the isolation of two new withanolides, withanone (295) and quresimine A (256) and 2,3 dihydrowithaferine A (297). The last section deals with the studies on the chemical constituents from Ferula oopoda which have sesquiterpene lactones guaianolide (304) and grilactone (305) for the first time from this species.

 
   
DOWNLOAD FULL THESIS
243.MB

Sr.No Chapter TABLE OF CONTENTS i 180.kbs
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1 1

GENERAL INTRODUCTION

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2 2 INTRODUCTION OF FUMARIA INDICA 44
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3 3 INTRODUCTION OF WITHANIA SOMNIFERA 119
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4 4 INTRODUCTION OF FERULA OOPODA 176
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5 5 REFERENCES 204
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6 6 LIST OF PUBLICATIONS 221
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