Pakistan Research Repository

ISOLATION AND STRUCTURAL ELUCIDATION OF CHEMICAL CONSTITUENTS FROM FUMARIA INDICA, FERULA OOPODA AND WITHANIA SOMNIFERA

Ahmed, Shakil (1998) ISOLATION AND STRUCTURAL ELUCIDATION OF CHEMICAL CONSTITUENTS FROM FUMARIA INDICA, FERULA OOPODA AND WITHANIA SOMNIFERA. PhD thesis, University of Karachi, Karachi.

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Abstract

Fumaria indica, Ferula oopoda , Withania somnifera, Alkaloids, Heterocyclic alkaloids, Isoquinoline alkaloids, Tetrahydroisoquinoline alkaloids, Biosynthesis of Isoquinoline Alkaloids, Pavine and Isopavine, Aporphine Alkaloids, Protoberberine Alkaloids, Protopine Alkaloids, Phthalideisoquinoline Alkaloids, Secophthalideisoquinoline Alkaloids, Fumaileal (144), Fumaileate (149), Papraline (143), 9, 10 Methylenedioxy karachine (255), Vanillin (142), Cryptopine (61), (+) B Hydrastine (232), Corydaldine (147), Withanolides, Quresimine, Withaferine A, 2,3 Dihydrowithaferine A, Feraileate, Guaianolide, Grilactone, Isolation, Structure elucidation, COSY 450, HOHAHA, HMBC, HMQC, The thesis presents the isolation and structure elucidation of various classes of natural products which were isolated from three medicinal plants of Pakistan, i.e. Fumaria indica, Withania somnifera and Ferula oopoda. The structure of the compounds were determined on the basis of sophisticated spectroscopic techniques including one and two dimensional NMR spectroscopic experiments such as COSY 45o, HOHAHA, HMBC, HMQC etc. Phytochemical investigations on Fumaria indica have led to the isolation of four new components i.e. papraline (143), 4,5 dimethoxy 2 hydroxybenzaldehyde (144), fumaileate (149) and 9,10 methylenedioxy karachine (255) along with the four known isoquinoline alkaloids, 4 hydroxy 3 methoxybenzaldehyde (142), cryptopine (61), (+) B hydroastine (232) and corydaldine (147). The next section of the thesis describes the chemical constituents of Withania somnifera and includes the isolation of two new withanolides, withanone (295) and quresimine A (256) and 2,3 dihydrowithaferine A (297). The last section deals with the studies on the chemical constituents from Ferula oopoda which have sesquiterpene lactones guaianolide (304) and grilactone (305) for the first time from this species

Item Type:Thesis (PhD)
Uncontrolled Keywords:Fumaria indica, Ferula oopoda , Withania somnifera, Alkaloids, Heterocyclic alkaloids, Isoquinoline alkaloids, Tetrahydroisoquinoline alkaloids, Biosynthesis of Isoquinoline Alkaloids, Pavine and Isopavine, Aporphine Alkaloids, Protoberberine Alkaloids, Protopine Alkaloids, Phthalideisoquinoline Alkaloids, Secophthalideisoquinoline Alkaloids, Fumaileal (144), Fumaileate (149), Papraline (143), 9, 10 Methylenedioxy karachine (255), Vanillin (142), Cryptopine (61), (+) B Hydrastine (232), Corydaldine (147), Withanolides, Quresimine, Withaferine A, 2,3 Dihydrowithaferine A, Feraileate, Guaianolide, Grilactone, Isolation, Structure elucidation, COSY 450, HOHAHA, HMBC, HMQC
Subjects:Physical Sciences (f) > Chemistry(f2) > Analytical chemistry(f2.2)
ID Code:54
Deposited By:Mr Ghulam Murtaza
Deposited On:17 Jun 2006
Last Modified:04 Oct 2007 20:59

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