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Title of Thesis

Pharmacokinetics, Bioavailbility, Urinary Excretion and Renal Clearance of Enrofloxacin and Norfloxacin After Oral and Intravenous Administration in Horses and Mules

Author(s)

Rehan Ahmad

Institute/University/Department Details
Department of Veterinary Physiology and Pharmacology / University of Agriculture, Faisalabad
Session
2005
Subject
Veterinary Pharmacology
Number of Pages
175
Keywords (Extracted from title, table of contents and abstract of thesis)
Bioavailbility, Mules, Administration, Pharmacokinetics, Excretion, Clearance, Urinary, Horses, Renal, Norfloxacin , Oral, Enrofloxacin, Intravenous

Abstract
Not Available

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1,766 KB
S. No. Chapter Title of the Chapters Page Size (KB)
1 0 CONTENTS

 

  
16 KB
2

1

 INTRODUCTION

 

 1
63 KB
3 2 REVIEW OF LITERATURE

2.1 History of Fluoroquinolones
2.2 Chemistry
2.3 Structure Activity Relationship
2.4 Mechanism of Action
2.5 Bacterial Resistance
2.6 Spectrum of Activity
2.7 Effect of Fluoroquinolones on Immune System
2.8 Adverse Effect
2.9 Drug Interaction
2.10 Pharmacokinetics of Fluoroquinolones
2.11 Renal Clearance of Fluoroquinolones

 3
247 KB
4 3 MATERIALS AND METHODS

3.1 Animals
3.2 Cannulation of Jugular Vein
3.3 Catheterization of Urinary Bladder
3.4 Drugs
3.5 Drug Administration
3.6 Collection of Blood Samples
3.7 Collection of Urinary Samples
3.8 Antibacterial Assay
3.9 Creatinine Analysis
3.10 Calculations
3.11 Statistical Analysis

 45
 154 KB
5 4 RESULTS

4.1 Plasma Concentrations
4.2 Pharmacokinetic Parameters
4.3 Dose Regimen
4.4 Urinary Excretion
4.5 Renal Clearance

 54
955 KB
6 5 DISSUASION

5.1 Microbiological Assay
5.2 Plasma Concentrations
5.3 Pharmacokinetic Parameters
5.4 Dose Regimen
5.5 Urinary Excretion
5.6 Renal Clearance
5.7 Recommendation for Future Studies

 121
141 KB
7 6 SUMMARY

6.1 Conclusions
6.2 Future Recommendations

 139
46 KB
8 7 REFERENCES

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114 KB