SYNTHESIS AND CHARACTERIZATION OF ORGANOTIN (IV) COMPLEXES WITH DONOR LIGANDS

Wajid Rehman, Gora (2005) SYNTHESIS AND CHARACTERIZATION OF ORGANOTIN (IV) COMPLEXES WITH DONOR LIGANDS. Doctoral thesis, Gomal University Dera Ismail Khan.

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Abstract

Organotin(IV) complexes with the general formulae RnSnL4-n and RnSn2Ln (R=alkyl, L =monomethyl glutarate, monomethyl phthalate, monomethyl (2-Phenyl glutarate) and Schiff bases of 2-aminophenol and salicylaldehyde) have been prepared.</p><p>These complexes have been synthesized by the reaction of organotin(V) complexes have been synthesized by the reaction of organotin(IV) oxide with the ligand. The reaction of organotin (IV) oxide with the ligand. The reaction is carried out at the reflux trmperature of benzene while water formed during the reaction is continuously removed by means of a Dean and Stark apparatus.</p><p>The reaction fo organotin(IV) oxides with organic ocids is more economical and gives better purities as the reaction of organotin(IV) halides with organic acids in the presence of a base.These complexes have been characterized by elemental analyses and molar conductivity. The chemical bonding in these complexes have been discussed in terms of their IR, 1H-, 13 C and 119Sn-NMR, mass and 119Sn-Mossbauer spectral studies.The 1H and 13C chemical shift assignments of the organotin moiety are straightforward from the multiplicity and intensity pattern, whereas the ligand skeletons were assigned by multiplicity pattern and/or resonance intensities of signals as well as their coupling constants. The alkyl groups attached shifts with those calculated from incremental methods or compared to the literature data.The monomeric 1:1 complexes have trigonal bipyramidal geometry with cisequitorial organic groups, the dimeric 1:2 complexes have octahedral geometry while complexes derived from a Schiff base of 2-aminphenol and salicyladehyde have tetrahedral geometries.Mass spectrum analyses reveal that the primary decomposition is due to the loss of a ligand incase of diorganotin(IV) complexes along with the successive elimination of a CO2 molecule while in triorganotin(IV) complexes the primary decomposition is due to the loss of an alkyl group along with the elimination of a CO2 molecule.The geometry assigned to these complexes is well supported by infrared and Mossauer studies.All these complexes, soluble in DMSO and DMF have been screened against a wide spectrum of bacteria (Bacillus subtills, Stapholococcus aureus, Escherichia coli, Schigella flexenari, Pseudomonas aeruginosa, and Salmonella typh) and fungi (C.capsici, C.glocosporiodes, A. brassicicola, A brassicae, H. graminium. The ALD50 values have been determined with albino rats. Some of the complexes exhibited very high anti-inflammatory activities. The cytostatic activity of the complexes exhibited very high anti-inflammatory activities. The cytostatic activity of the complexes has been assayed against the established cell line KB, which has been derived from a human oral epidermoid carcinoma. The results obtained are quite promising.Overall, triorganotin(IV) derivatives exhibit significantly better activities than the diorganotin(IV) complexes.

Item Type: Thesis (Doctoral)
Uncontrolled Keywords: organotin, ligands, halides, bacteria, bacillus subtills, stapholococcus aureus, escherichia coli, schigella flexenari, pseudomonas aeruginosa, salmonella typh, fungi, c.capsici, c.glocosporiodes, a. brassicicola, a brassicae, h. graminium, metallic tin, organotin carboxylates
Subjects: Q Science > QD Chemistry
Depositing User: Mr Sami Uddin
Date Deposited: 28 Jul 2017 06:45
Last Modified: 28 Jul 2017 06:45
URI: http://eprints.hec.gov.pk/id/eprint/4182

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