Title of Thesis

Chemical Investigations on the Bioactive Constituents of Vernonia, Related Medicinal Plants and a-Glucosidase Inhibition Studies on Natural and Synthetic Compounds

Author (s)

SHAMS-UN-NAHAR KHAN

Institute/University/Department Details

International Centre for Chemical and Biological Sciences, H.E.J Research Institute of Chemistry / University of Karachi, Karachi

Subject

Chemistry

Chemical, Investigations, Bioactive, Vernonia, Medicinal Plants, Glucosidase, Synthetic, Compounds

Abstract

Not Available.

1.1 Enzymes and Living System

1.2 Major Classes of Enzymes

1.3 Enzyme Inhibitors and Kinetics

1.4 Clinically Used Enzyme Inhibitors

1.5 Glycosyl Hydrolases

1.6 Clinical Significance of a-Glucosidase Inhibition

1.7 Application of Three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) Studies in Search of

      a-Glucosidase Inhibitors

1.8 Brief Account and Objectives of the Current Study of a-Glucosidase Inhibitors

2.1 Assessment of the a-Glucosidase Inhibitory Activity

2.2 In Vivo Antihyperglycemic Assays in Experimental Animals

2.3 Methods of Cytotoxicity Assessment against BALB/c 3T3 Cell Line

2.4 Three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) Studies

2.5 Homology Model of Yeast a-Glucosidase (EC 3.2.1.20)

2.6 Molecular Docking Studies by 'AutoDock' Software

3.1 a-Glucosidase Inhibitors of Natural Origin

3.2 a-Glucosidase Inhibition Studies on Synthetic Compounds

3.3 In Vivo Studies of B-Amyrin Acetate (72) as Intestinal a-Glucosidase Inhibitors

3.4 Homology Modeling

4.1 Introduction

4.2 Experimental Section

4.3 Results and Discussion

5.1 Introduction

5.2 Experimental Section

5.3 Results and Discussion