I=
Pakistan Research Repository Home
 

Title of Thesis

Chemical Investigations on the Bioactive Constituents of Vernonia, Related Medicinal Plants and a-Glucosidase Inhibition Studies on Natural and Synthetic Compounds

Author (s)

SHAMS-UN-NAHAR KHAN

Institute/University/Department Details

International Centre for Chemical and Biological Sciences, H.E.J Research Institute of Chemistry / University of Karachi, Karachi

Session
2008

Subject

Chemistry

Number of Pages
344
Keywords (Extracted from title, table of contents and abstract of thesis)
 

Chemical, Investigations, Bioactive, Vernonia, Medicinal Plants, Glucosidase, Synthetic, Compounds

Abstract

Not Available.

Download Full Thesis
18,272 KB
S. No. Chapter Title of the Chapters Page Size (KB)
1 0 CONTENTS  
537 KB
2 1 INTRODUCTION

1.1 Enzymes and Living System

1.2 Major Classes of Enzymes

1.3 Enzyme Inhibitors and Kinetics

1.4 Clinically Used Enzyme Inhibitors

1.5 Glycosyl Hydrolases

1.6 Clinical Significance of a-Glucosidase Inhibition

1.7 Application of Three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) Studies in Search of

      a-Glucosidase Inhibitors

1.8 Brief Account and Objectives of the Current Study of a-Glucosidase Inhibitors

1
3,723 KB
3 2 EXPERIMENTAL SECTION

2.1 Assessment of the a-Glucosidase Inhibitory Activity

2.2 In Vivo Antihyperglycemic Assays in Experimental Animals

2.3 Methods of Cytotoxicity Assessment against BALB/c 3T3 Cell Line

2.4 Three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) Studies

2.5 Homology Model of Yeast a-Glucosidase (EC 3.2.1.20)

2.6 Molecular Docking Studies by 'AutoDock' Software

43
1,201 KB
4 3 RESULTS AND DISCUSSION

3.1 a-Glucosidase Inhibitors of Natural Origin

3.2 a-Glucosidase Inhibition Studies on Synthetic Compounds

3.3 In Vivo Studies of B-Amyrin Acetate (72) as Intestinal a-Glucosidase Inhibitors

3.4 Homology Modeling

63
9,202 KB
5 4 PHYTOCHEMICAL INVESTIGATION ON SECONDARY METABOLITES ON GREWIA MICROCOS LINN

4.1 Introduction

4.2 Experimental Section

4.3 Results and Discussion

268
847 KB
6 5 PHYTOCHEMICAL STUDIES ON VERNNONIA ANTHELMINTICA WILD

5.1 Introduction

5.2 Experimental Section

5.3 Results and Discussion

283
264 KB
7 6 REFERENCES

 

290
1,142 KB