ISOLATION AND BIOTRANSFORMATION OF SOME BIOACTIVE COMPOUNDS FROM MEDICAL PLANTS

Humaira Yaseen, Gondal (2004) ISOLATION AND BIOTRANSFORMATION OF SOME BIOACTIVE COMPOUNDS FROM MEDICAL PLANTS. Doctoral thesis, University of Karachi/ H.E.J. Research Institute of Chemistry.

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Abstract

The work presented in this Ph.D dissertation is divided in three parts. Part-A deals with phytochemical studies on suregada multiflora, a medicinal plant of Bangladesh, Part-B deals with photochemical studies on Verbascum sinaiticum, while microbial transformations of some natural compounds are discussed in Part-C. Part-A, This part of thesis deals with photochemical investigation on the leaf extracts of Suregada multiflora. The crude extract of Suregada multiflora was found to possess selective and significant cytotoxicity against a 60-cell line tumor panels at the isolation of eleven different tetracyclic diterpene lactores 1-11, which are the members of a rare class of abiatene diterpene lactrones along with a flavonoid glycoside and a lignan Compounds 7-11 (Gelomulide F, D, E, A and G), isolated from suregada multiflora were evaluated in the primary anticancer assay of 3-cell lines at the National Cancer Institute (NCI) Bethesda, USA. Out of them compound 9 (Gelomulide E) showed promising activity against the NCI-H460 (Lung) cell line, with a growth inhibition of over 85% at concentration of 5X10-5M New diterpene lactones from suregada multiflora Six new compounds (1-6) have been isolated from the Suregada multiflora. Among them compounds 1 and 2 contain an epoxy linkage between C-8 and C-14, whereas compounds 3-5 were identified as 8-14-dihydroxy analogues of diterpene lactones. Compound 6 contains one additional epoxy ring between C-11 and C-12

Item Type: Thesis (Doctoral)
Uncontrolled Keywords: bioactive compounds, medical plants, suregada multiflora, verbascum sinaiticum, microbial transformations, anticancer assay
Subjects: Q Science > QD Chemistry
Depositing User: Unnamed user with email jmemon@hec.gov.pk
Date Deposited: 19 Jul 2017 07:31
Last Modified: 19 Jul 2017 07:31
URI: http://eprints.hec.gov.pk/id/eprint/3778

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