I= SOCIO – ECONOMIC CONSEQUENCES OF RETURN MIGRATION AND THE ADJUSTMENT PROBLEMS IN PUNJAB Title of Thesis


Pakistan Research Repository

 

 

 

 

 

 

Title of Thesis

FORMULATION RELEASE AND BIO AVAILABILITY STUDY OF SOME IMPORTANT DRUGS FROM VARIOUS SUPPOSITORY BASES

Author(s)

Wilayat Ahmad

Institute/University/Department Details

University of the Punjab, Lahore / Veterinary Microbiology

Session

2001

Subject

Faculty of Pharmacy

Number of Pages

187

 

Keywords (Extracted from title, table of contents and abstract of thesis)

Nausea, Vomiting, And Gastric, Drugs, Suppositories, Formulation Release, Diclofenac Sodium, Ibuprofen, Amodiaquine Hydrochloride, Chloroquine Phosphate

 

Abstract

In view of the problems such as nausea, vomiting, and gastric associated with oral administration of drugs, for which parenteral administration in some cases is not recommended, We made an attempt to prepare suppositories for some of the drugs for which such means drug delivery are not available. The suppositories of Diclofenac sodium, Ibuprofen, Amodiaquine hydrochloride and Chloroquine phosphate were prepared by fusion method with various bases including Cocoa butter, Witepsol H 15, Witepsol W 25, Witepsol W 35, and Witepsol E 75 and by non-fusion method in a mixture of Eudragit L & propylene glycol. Release rate of the drugs from these suppositories was dependent on the nature of base employed and quantitatively release was in the order Cocoa butter> Witepsol H 15 > Witepsol W 25 > Witepsol W 35 > Witepsol E 75. Formulation of Eudragit L suppositories indicated slow and insufficient release. The hydrophobic nature of lbuprofen presented slower release as compared to other drugs in the present study. Drug release from our formulations in the present work reveals a suitability of such preparations for therapeutic purpose, keeping in view the properties such as melting point, partition coefficient and dissolution in appropriate media. The bioavailability of the drugs from these preparations in rabbits corresponded well with the in vitro release of drugs from the suppositories.

 

Download Full Thesis

180.kbs

1074 KB

 

S. No. Chapter Title of the Chapters

Page

Size (KB)

    Table of Contents  

180.kbs
1875 KB

1 1 INTRODUCTION 1

180.kbs
1521 KB

       
       
       
2 2 REVIEW OF LITERATURE 3

180.kbs

226 KB

 

       
       
       
       
3 3 MATERIALS AND METHODS 24

180.kbs

175 KB

 

       
       
       
4 4 RESULTS 41

180.kbs

1168 KB

 

       
       
5 5 DISCUSSION

173

180.kbs

73 KB

6 6 SUMMARY

179

180.kbs

15 KB

7 7 REFERENCES

180

180.kbs

312 KB