I= SOCIO ā€“ ECONOMIC CONSEQUENCES OF RETURN MIGRATION AND THE ADJUSTMENT PROBLEMS IN PUNJAB Title of Thesis


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Title of Thesis

SYNTHESIS OF NOVEL PYRAZOLES

Author(s)

Sabiha Rashid

Institute/University/Department Details

Islamia University, Bahawalpur / Chemistry

Session

1995

Subject

Chemistry

Number of Pages

177

 

Keywords (Extracted from title, table of contents and abstract of thesis)

Novel Pyrazoles, Hetarylpyrazolcs, 2-(1-Arylpyrazol-4-Y1)Benzimidazoles, Pyrazolylbenzimidazoles, 2-(1-Arylpyrazol-4-Yl)Benzimidazoles, 4-(L-Arylpyrazol-4-Yl)Pyridines, 4-(L-Arylpyrazol-4-Yl)Pyridines Esters, (L-Arylpyrazol-4ā€™-Yl)-1-3-4-Oxadiazoles, 4-5-Dipyrazolyls, (Lā€™-Arylpyrazol-4-Yl)Isoxazoles, 4-5-Dipyrazolyls, (Lā€™-Arylpyrazol-4-Yl)Soxazoles, 2-(Arylpyrazol-4-Yl)Tetrazole, (Arylpyrazol-4-Yl)Trizoles

 

Abstract

The present work describes attempts to prepare hetarylpyrazolcs in the expectation that they might possess useful antimicrobial activity. Synthesis of 2-(l'-arylpyrazol 4'-yl) benzimidazoles (I) was carried out by the condensation of arylpyrazoles 4'-carboxaldehyde with o-phenylinediamine and 4-nitro-o-phenylinediamine. 4-(1'-arylpyrazol 4'-yl) pyridincs (II) were prepared by the condensation of arylpyrazole with ethyl acetoacetate in the - presence of ammonia. While, 5-(1 '-aryl pyrazol 4'-yl)-1, 3, 4-oxadiazoles (III) were obtained by the condensation of benzhydrazide with arylpyrazol 4-carboxaldehydes followed by cyclization of the intermediates. 4, 5-Dipyrazolyls (IV), and 3-(1'-aryl-4'-pyrazolyl) isoxazoles (V) were prepared by the condensation of arylpyrazoles with acetone, acetophenone and then with phenylhydrazine hydrochloride, hydrazine hydrochloride and hydroxylamine hydrochloride, respectively. The structure of these hetarylpyrazoles thus synthesized were determined on the basis of their elemental analysis, infrared, proton magnetic resonance and mass spectra. Antibacterial activities of the hetarylpyrazoles synthesized during, this work were also determined again st Staphylococcus aureus, Staphyloaurens cocci, Pseudomonas and Escherichia coli employing Agar Plate Disc method. Some of the products were active but not to the extent as compared with the antibiotics in clinical use.

 

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    Table of Contents  

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1 1 INTRODUCTION AND LITERATURE SURVEY 1

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2 2 MATERIALS AND METHODS 59

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3 3 EXPERIMENTAL 60

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4 4 RESULTS AND DISCUSSION 138

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5 5 ANTIBACTERIAL ACTIVITY

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6 6 REFERENCES

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