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SYNTHESIS OF NOVEL PYRAZOLES

Rashid, Sabiha (1995) SYNTHESIS OF NOVEL PYRAZOLES. PhD thesis, Islamia University, Bahawalpur.

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Abstract

The present work describes attempts to prepare hetarylpyrazolcs in the expectation that they might possess useful antimicrobial activity. Synthesis of 2-(l'-arylpyrazol 4'-yl) benzimidazoles (I) was carried out by the condensation of arylpyrazoles 4'-carboxaldehyde with o-phenylinediamine and 4-nitro-o-phenylinediamine. 4-(1'-arylpyrazol 4'-yl) pyridincs (II) were prepared by the condensation of arylpyrazole with ethyl acetoacetate in the - presence of ammonia. While, 5-(1 '-aryl pyrazol 4'-yl)-1, 3, 4-oxadiazoles (III) were obtained by the condensation of benzhydrazide with arylpyrazol 4-carboxaldehydes followed by cyclization of the intermediates. 4, 5-Dipyrazolyls (IV), and 3-(1'-aryl-4'-pyrazolyl) isoxazoles (V) were prepared by the condensation of arylpyrazoles with acetone, acetophenone and then with phenylhydrazine hydrochloride, hydrazine hydrochloride and hydroxylamine hydrochloride, respectively. The structure of these hetarylpyrazoles thus synthesized were determined on the basis of their elemental analysis, infrared, proton magnetic resonance and mass spectra. Antibacterial activities of the hetarylpyrazoles synthesized during, this work were also determined again st Staphylococcus aureus, Staphyloaurens cocci, Pseudomonas and Escherichia coli employing Agar Plate Disc method. Some of the products were active but not to the extent as compared with the antibiotics in clinical use.

Item Type:Thesis (PhD)
Uncontrolled Keywords:Novel Pyrazoles, Hetarylpyrazolcs, 2-(1-Arylpyrazol-4-Y1)Benzimidazoles, Pyrazolylbenzimidazoles, 2-(1-Arylpyrazol-4-Yl)Benzimidazoles, 4-(L-Arylpyrazol-4-Yl)Pyridines, 4-(L-Arylpyrazol-4-Yl)Pyridines Esters, (L-Arylpyrazol-4’-Yl)-1-3-4-Oxadiazoles, 4-5-Dipyrazolyls, (L’-Arylpyrazol-4-Yl)Isoxazoles, 4-5-Dipyrazolyls, (L’-Arylpyrazol-4-Yl)Soxazoles, 2-(Arylpyrazol-4-Yl)Tetrazole, (Arylpyrazol-4-Yl)Trizoles
Subjects:Physical Sciences (f) > Chemistry(f2)
ID Code:349
Deposited By:Mr Ghulam Murtaza
Deposited On:28 Jun 2006
Last Modified:04 Oct 2007 21:00

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