Pakistan Research Repository Home
 

Title of Thesis

Iron Chelation and Disposition Knetics of Deferiprone in Male Human Beings

Author (s)
Mateen Abbas
Institute/University/Department Details
University of Agriculture Faisalabad, Pakistan
Session
2009
Subject
Chemistry
Number of Pages
230
Keywords (Extracted from title, table of contents and abstract of thesis)
 

Abstract

 

 

         
Full Thesis

 


1910 KB
S. No. Chapter Title of the Chapters Page Size (KB)
1 1 Introduction 1
98 KB
       
       
 
2 2 Review of Literature 12

 

 

 

 


278 KB

  2.1 Iron Physiology 12
  2.2 Thalassemia 17
  2.3 Molecular and cellular pathology 19
  2.4 Iron Storage Disease 21
  2.5 Clinical manifestations and supportive therapy (Transfusion therapy) 23
  2.6 Iron Overload (Pathogenesis) in Human 23
  2.7 Hazards of Iron Loading 25
  2.8 Iron toxicity (Redox Activity of Iron) 25
  2.9 Diagnostic Strategies in Iron Overload 28
  2.10 Treatment of Iron Overload 30
  2.11 Iron Chelation 30
  2.12 Advantages of Deferiprone 33
  2.13 Deferiprone 33
  2.14 Deferiprone 48
         
3 3 Materials and Methods 51  

 

 


166 KB

  3.1 Study Design 51
  3.2 Ethics 51
  3.3 Study Subjects 52
  3.4 Subject and Informed Consent 53
  3.5 Clinical Chemistry Data 54
  3.6 Demographic and Baseline Characteristics 56
  3.7 Label Information 58
  3.8 Drug Dosage and Administration 58
  3.9 Concomitant Therapy 58
  3.10 Sample Collection and Handling 58
  3.11 Analytical Procedure 59
  3.12 Safety Evaluations 63
  3.13 Calculation 64
  3.14 Statistical Methods 66
         
4 4 Results 67
1020 KB
  4.1 Validation of Analytical Method 68
  4.2 Disposition Kinetics of Deferiprone 76
  4.3 Renal Clearance 82
  4.4 Urinary Excretion 87
         
5 5 Discussion 99
128 KB
  5.1 Validation of Analytical Method 100
  5.2 Disposition Kinetics of Deferiprone 101
  5.3 Renal Clearance 103
  5.4 Renal Clearance 105
         
6 6 Summary 110
341 KB
       
       
7   Literature Cited 112

173 KB

       
       
8   Appendix 135

173 KB