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| Pakistan Research Repository | Home |
Title of Thesis Hepatitis C Virus Persistence: Virus and Host Related Factors |
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| Author (s) Aneela Yasmeen |
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| Institute/University/Department Details Aga Khan University, Karachi |
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| Session 2005 |
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| Subject Bio Chemistry |
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| Number of Pages 182 |
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| Keywords (Extracted from title, table of contents and abstract of thesis) |
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Abstract |
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| S. No. | Chapter | Title of the Chapters | Page | Size (KB) |
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| 1 | 1 | Hepatitis C virus: an overview | 1 | |
| 1.1 | Introduction | 1 | ||
| 1.2 | Genomic organization | 1 | ||
| 1.3 | Geographical distribution of HCV genotypes | 2 |  356 KB |
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| 1.4 | Epidemiology | 5 | ||
| 1.5 | Current strategies | 20 | ||
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| 2 | 2 | Phylogenetic Analysis of HCV Isolates in Pakistan | ||
| 2.1 | Introduction | 25 |
621 KB
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| 2.2 | HCV Genotypes | 25 | ||
| 2.3 | Hypothesis | 39 | ||
| 2.4. | Aims | 39 | ||
| 2.5 | Materials and Methods | 40 | ||
| 2.6 | Results | 47 | ||
| 2.7 | Discussion | 58 | ||
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| 3 | 3 | HCV IRES Translation Efficiency | ||
| 3.1 | Introduction | 61 | ||
| 3.2 | Virus Related Factors | 61 |
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| 3.3 | Hypothesis | 71 | ||
| 3.4 | Aims | 71 | ||
| 3.5 | Material and Methods | 72 | ||
| 3.6 | Results | 83 | ||
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| 4 | 4 | Host related Factors in Viral Persistence | 388 KB
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| 4.1 | Introduction | 101 | ||
| 4.2 | Host-Virus Interaction | 101 | ||
| 4.3 | Hypothesis | 106 | ||
| 4.4 | Aims | 106 | ||
| 4.5 | Material and Methods | 107 | ||
| 4.6 | Results | 109 | ||
| 4.7 | Discussion | 117 | ||
| 4.8 | Host Immune Status | 119 | ||
| 4.9 | Hypothesis | 125 | ||
| 4.10 | Aims | 125 | ||
| 4.11 | Materials and Methods | 126 | ||
| 4.12 | Results | 131 |
42 KB
167 KB |
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| 4.13 | Discussion | 135 | ||
| 5 | 5 | Conclusion | 138 | |
| 6 | 6 | Bibliography | 140 | |
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