Anwar, Munir (2008) THE PHARMACOGNOSTIC AND PHARMACOLOGICAL STUDIES ON MEDICINAL VALUED HERBAL DRUGS, ERYTHRINA VARIEGATA VAR. ORIENTALIS, MATRICARIA CHAMOMILLA, PSORALEA CORYLIFOLIA AND CHENOPODIUM ALBUM. PhD thesis, University of Karachi, Karachi.
Four different plants of medicinal value namely; Erythrina variegata, Matricaria chamomilla, Psoralea corylifolia and Chenopodium album were selected for evaluation and assessment of therapeutic value. Pharmacognostical, diagnostic and Pharmacological studies were conducted along with standardized methods for quality control and assurance to provide a base line to commercialize their constituents for herbal products. The WHO recommendations for evaluation were utilized for the characterization of these plants. Three new and 14 known compounds were isolated from Erythrina variegata and a scientific paper was published in the international journal. The smooth muscles studies on crude extract of E. variegata and their fractions had shown inhibitory response. Treatment of tissue with standard drugs along with fractions showed the possible involvement of both adrenergic and muscarinic receptors but the influence of adrenergic receptors or others was more than muscarinic receptors. It is an inhibitory effect which slowed down the action of the smooth muscles. A significant Antioxidant activity (63.5%) of crude extract of E. variegata was noted. Antioxidants are products that hinder the oxidative processes and potential value of antioxidants in eradicating oxidative stress has provoked researchers to investigate for natural compounds with potent antioxidative activity but showing low cytotoxity. Analgesic activity exhibited onset of action with in 30 minutes which lasted for 90 minutes, indicating sedative action of the drug which is CNS depressive effect. Studies concluded that this drug can be utilized as sedative in formulations. Smooth muscles study of Matricaria chamomilla showed mix type of responses on smooth muscles on various dose strengths. The study suggested to separate active constituents having stimulating and relaxing effects in order to explore possible development of a treatment therapy. M chamomilla showed analgesic activity that started at 30 minutes and continued till 120 minutes on higher dose which may be due to the inhibition of the muscarinic and H2 receptors as seen similar effect in the smooth muscle activity which may lead to provide an effective therapeutic option to protect against NSAIDs induced gastric ulcers. Mice had shown loss of grip (relaxant effect) and tremor for 2-3 seconds on dose modulation during behavioral study. Staphylococcus aureus, Eschererichia coli and Candida albicans were found sensitive to M chamomilla showing importance as an antimicrobial entity. Study on the crude extract of P. corylifolia and its fractions revealed quick decrease in the normal intestinal movement followed by a gradual increase in the form of curve. These results at different dosage indicated the presence of mix effect. This is because of the presence of more then one phamacologically active constituent. Gross behavioral studies on crude extract of this plant showed slight irritability on lower dose which reflects the CNS stimulatory effect with the increase in spontaneous activity. At higher dose, the passivity was observed. Overall, there was CNS stimulant effect found in P. corylifolia. At the same time, significant Analgesic effect was observed on lower and higher doses. Smooth muscles studies performed on the crude extract and fractions of C. album revealed its mixed response on the rabbit intestinal muscles. Extract showed relaxing effect initially followed by the contraction of muscle with the increase in dose regimen. Significant antioxidant activity of crude extract of C. album was noted (67.3%). High antioxidant activity can lead to reduction of free oxygen radicals and can help in recovering or can be used in combination therapy to improve quality of life in diseases like cancer, heart/artery disease, essential hypertension, Alzheimer's dementia, cataracts, diabetes, Parkinson's disease, arthritis and inflammatory disease, as well as aging. C. album had shown strong agglutination activity against A+ and O+ leading to possible lectine like action. Studies concluded that the plant has strong stimulant effect acting on central nervous system. Spectroscopic evaluation of these plants was reported first time and chromatograms were attached for standardization of drugs of commercial value.
|Item Type:||Thesis (PhD)|
|Uncontrolled Keywords:||erythrina variegata, matricaria chamomilla, psoralea corylifolia, chenopodium album, herbal drugs, therapeutic value|
|Subjects:||Biological & Medical Sciences (c) > Medical Sciences (c2) > Pharmacy(c2.5)|
|Deposited By:||Mr. Javed Memon|
|Deposited On:||05 Aug 2009 12:10|
|Last Modified:||07 Oct 2009 13:53|
Repository Staff Only: item control page