AHMAD, MANZOOR (2006) ISOLATION AND CHARACTERIZATION OF SECONDARY METABOLITES FROM MYRTUS COMMUNIS LINN, DELPHINIUM ROYLEI MUNZ AND RELATED MEDICINAL PLANTS. PhD thesis, University of Karachi, Karachi.
This Ph.D. thesis describes the phytochemical and biological investigations of traditionally used medicinal plants of Northern areas of Pakistan. The study is mainly divided into three parts: Part A describes a phytochemical work on Myrtus communis Linn. Part B on Delphinium roylei Munz. and Part C on Aconitum laeve Royle. Part A Four new acyphloroglucinols myrtucommulone-D (1), myrtucommulone-E (2), myrtucommulone-C (3), 5-demethylsemimyrtucommulone (4); an usnic acid derivative, usnone-A (5); and a known acylphloroglucinol, myrtucommulone-B (6); six triterpenes 10-15; two flavonoids 7-8; 2,5-dihydroxy-4-methoxybenzophenone (cearoin) (9); and ÃŸ-sitosterol (16) have been isolated from Myrtus communis Linn. The compounds 1-4, and 6 were found to be potent Î±-glucosidase inhibitors. The compound 3 exhibited the highest activity among all the acylphloroglucinols, with an IC50 = 35.4 Â± 1.15 ÂµM. The compounds 1,2,5,9, and 11-16 also exhibited antibacterial activities. Part B The phytochemical investigations on Delphinium roylei Munz. yielded eight known norditerpenoid alkaloids 1-8. Compounds 3-6 were isolated for the first time from this plant. A new lycoctonine-type norditerpenoid alkaloid, swatinine (1), along with four known norditerpenoid alkaloids, delphatine (3), puberanine (4), N-acetylsepaconitine (5), and lappaconitine (6), and a benzene derivative, 4-[2-(methoxycarbonyl) anilino]-4-oxobutanoic acid (2), were isolated from the aerial parts of Aconitum laeve Royle Compound 2 was isolated for the first time from a natural source. The anti-inflammatory, antioxidant, and tyrosinase inhibition studies on all six compounds 1-6 were carried out.
|Item Type:||Thesis (PhD)|
|Uncontrolled Keywords:||secondary metabolites, myrtus communis linn, delphinium roylei munz, medicinal plants, aconitum laeve royle, acyphloroglucinols myrtucommulone, swatinine, myrtus, delphinium, diterpenoid alkaloids, aconitum|
|Subjects:||Physical Sciences (f) > Chemistry(f2)|
|Deposited By:||Mr. Javed Memon|
|Deposited On:||20 Jul 2009 13:46|
|Last Modified:||20 Jul 2009 13:46|
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