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STUDIES IN THE CHEMICAL CONSTITUENTS OF PLUCHEA WALLICHIANA AND SORBUS CASHMIRIANA

KAZMI, SYED MEHDI HASSAN (2008) STUDIES IN THE CHEMICAL CONSTITUENTS OF PLUCHEA WALLICHIANA AND SORBUS CASHMIRIANA. PhD thesis, University of Karachi, Karachi.

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Abstract

God has gifted Pakistan with enormous varieties of medicinal plants. Out of these only 20% have so far been evaluated for their therapeutic potentials. Therefore, there is a need of coordinated and well-organized efforts in the area of chemistry of indigenous medicinal plants. The present Ph.D theses deals with the studies on two indigenous medicinal plants of Pakistan namely “Pluchea wallichiana” and “Sorbus cashmiriana” The thesis is therefore, presented in the following two parts: PART-AStudies in the chemical constituents of Pluchea wallichiana PART-BStudies in the chemical constituents of Sorbus cashmiriana PART-A Pluchea wallichiana belongs to the family Compositae (Asteraceae). A genus of shrub or under shrubs, rarely herbs distributed in the tropical and subtropical regions of the world. Pluchea walichiana is traditionally used in phytomedicine as, anti-oxidative, antihepatitis, antiulcerogenic, unfilorotic, inflammatory and has antipyretic properties. The leaves are commonly used for wound sores, skin diseases etc. Compounds isolated for the first time from Pluchea wallichiana are described below. Compound isolated for the first time from Pluchea wallichiana 1.P -Amyrin(65) 2 P -Amyrin acetate (66) 3(+) – Syringaresinol (67) 4ent-Pimara- 8 (14), 15-dien-19-oic acid (68) 5 Pluviatilol (69) 6. P -Sitosterol (70) 7.P -Sitosterol 3-0- p -D – glucopyranoside (71) 8.Apigenin 7-0- p -D-glucoside (72) 9.2-Hydroxy benzoic acid (73) 10 Benzoic acid (74) 114-Hydroxy benzoic acid (75) 12 Ethyl gallate (76) 13 Taraxasterol (77) 14 Taraxasterol acetate (78) 15 Lupeol (79) 16 Lupeol acetate (80) 1716a -hydroxy-ent-Kauran-19-oic acid.(81) 18 15, 16-Hydroxypimer-8 (14)-en-19-oic acid (82) PART-B Sorbus cashmiriana Hedlund, Monog is a tree of two seasons, one in the spring with the lovely pink-tinted flowers and one in the autumn when the leaves are gone and glorious white fruits shine out. It is distributed in Kashmir and the western Himalayas. There are about one hundred species under the genus Sorbus and seven are a native to the Indo-Pakistan Subcontinent. A tea made from its bark is used to treat nausea and to cleanse the blood. A bark preparation is also used against heart diseases. The berries are rich in vitamin C and used to cure scurvy. The ethnopharmacological and chemotaxonomic importance of the genus Sorbus led us to investigate the chemical constituents of S. cashmiriana. New Compounds isolated from Sorbus cashmiriana……….

Item Type:Thesis (PhD)
Uncontrolled Keywords:pluchea wallichiana, sorbus cashmiriana, medicinal plants, compositae, genus sorbus, terpenoids, squalene, resoceae
Subjects:Physical Sciences (f) > Chemistry(f2)
ID Code:2658
Deposited By:Mr. Javed Memon
Deposited On:20 Jul 2009 13:38
Last Modified:10 Oct 2009 17:50

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