I= PHARMACOLOGICAL EFFECTS OF EXTRACTS FROM MEDICINAL PLANTS ‚€œOLEA EROPEA, MYRISTICA FRAGRANS AND AMMI VISNAGA‚€Ě ON VOLUME AND ACIDY OF STIMULATED GASTRIC SECRETION, LIVER AND KIDNEY FUNCTIONS
Pakistan Research Repository Home
 

Title of Thesis
PHARMACOLOGICAL EFFECTS OF EXTRACTS FROM MEDICINAL PLANTS ‚€œOLEA EROPEA, MYRISTICA FRAGRANS AND AMMI VISNAGA‚€Ě ON VOLUME AND ACIDY OF STIMULATED GASTRIC SECRETION, LIVER AND KIDNEY FUNCTIONS

Author(s)
Dr. Muhammad Jan
Institute/University/Department Details
Faculty of Biological Sciences/ Quaid-i-Azam University Islamabad
Session
2006
Subject
Pharmacology
Number of Pages
116
Keywords (Extracted from title, table of contents and abstract of thesis)
medicinal plants, olea eropea, myristica fragrans, ammi visnaga, gastric secretion, liver function, kidney function, peptic ulcer, calcium channel blockers, gastric acid, gastric mucosa

Abstract
Increased production of hydrochloric acid by the gastric parietal cells is an independent and main factor for peptic ulcer. If ulcer is not prevented by proper treatment, it may lead to perforation and dangerous complications. Nowadays peptic ulcer is the common ailment, a physician comes across. The available drugs for peptic ulcer are very costly and have many adverse effects. As calcium ions play an important role in gastric acid secretion therefore, the present study was designed to choose those local, cheap and easily available medicinal plants that contain documented calcium channel blockers.

For this purpose extracts of three medicinal plants Olea europea, Myristica fragrans and Ammi visnaga were used. Their effects were observed on the volume and acidity of gastric secretion and were also compared with those of synthetic calcium channel blocker Verapamil and standard anti ulcer drug cimetidine, on the same parameters.

For this study two hundred forty rabbits were divided into twenty four groups of ten animals each. The first thirteen groups were used for low dose studies and are referred to as Category A. The second groups from fourteen to twenty four were used for high dose studies and are referred to as Category B. The last three groups in each category were tested for liver & kidney functions. The gastric contents were tested for volume and acidity. The data thus obtained was analyzed statistically.

It was observed that all the extracts reduced the volume and acidity significantly and the mean values were near to calcium channel blocker verapamil and the standard anti ulcer drug cimetidine. Combinations of two extracts were more effective than cimetidine and verapamil. It was also observed that after 45 days treatment with low and high doses in the last three groups of each category, there was no significant change in the mean values of kidney and liver functions. It indicated that the extracts can be safely used.

It is concluded that these extracts can effectively decrease gastric acid secretion and can even be safely used by way of crude extracts which is cost effective for poor masses. The possibility of these extracts being used in future for other such diseases where calcium channel blockers are being used.

Download Full Thesis
2979.21 KB
S. No. Chapter Title of the Chapters Page Size (KB)
1 0 Contents
364.96 KB
2 1 Introduction 1
740.77 KB
  1.1 Phases Of Gastric Secretion 3
  1.2 Regulation Of Gastric Acid Secretion 3
  1.3 Mechanism Of Hydrochloric Acid Secretion 9
  1.4 Protection Of Gastric Mucosa 10
  1.5 Feedback Inhibition Of Gastric Secretion By Excess Acid 11
  1.6 Conditions Associated With Increased Gastric Acid Secretion 11
  1.7 Role Of Calcium Channel Blockers 11
  1.8 History Of Calcium Antagonists 11
  1.9 Brief Pharmacology Of Drugs Used In This Study 16
  1.10 Brief Review Of The Extracts From Medicinal Plants And Their Pharmacological Actions 17
  1.11 Purpose Of Study 23
3 2 Materials And Methods 25
193.56 KB
  2.1 Collection And Identification Of Plants 25
  2.2 Selection Of Animals 25
  2.3 Blood Sampling 25
  2.4 Drugs And Extracts Used 26
  2.5 Chemical And Instruments Used 26
  2.6 Preparation Of Extraction 27
  2.7 Experimental Procedure Adopted In This Study 27
  2.8 Estimation Kidney And Liver Functions 29
  2.9 Short Terms Ether Anesthesia 30
  2.10 Analysis Of Acidity In Gastric Secretion 31
  2.11 Statistical Analysis 32
4 3 Results 33
1431.08 KB
  3.1 Low Dose Studies (Category A ) 33
  3.2 High Dose Studies (Category B ) 68
5 4 Discussion 99
185.43 KB
6 5 References 105
222.67 KB