I= PHYTOCHEMICAL AND STRUCTURAL STUDIES ON THE CHEMICAL CONSTITUENTS OF IRIS GERMANICA, COCCULUS PENDULUS AND RELATED MEDICINAL PLANTS
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Title of Thesis
PHYTOCHEMICAL AND STRUCTURAL STUDIES ON THE CHEMICAL CONSTITUENTS OF IRIS GERMANICA, COCCULUS PENDULUS AND RELATED MEDICINAL PLANTS

Author(s)
Atia-Tul-Wahab
Institute/University/Department Details
H.E.J. Research Institute of Chemistry/ University of Karachi
Session
2007
Subject
Chemistry
Number of Pages
252
Keywords (Extracted from title, table of contents and abstract of thesis)
iris germanica, cocculus pendulus, medicinal plants, aconitum karakolicum rapaics

Abstract
The work embodied in this Ph.D. dissertation is divided into four parts: first, phytochemical investigation on medicinally important plants, Iris germanica Linn. (Part A), Cocculus pendulus (Forst. and Diels) (Part B) and Aconitum karakolicum Rapaics. (Part C), which led the isolation and characterization of several new and known constituents. Second, antioxidant and cholinesterase inhibitory activities of the compounds isolated from the above-mentioned plants.

Part A: This part presents results of studies on the rhizomes of Iris germanica of Turkish origin. The introduction includes a brief review of earlier studies on the chemical constituents and the biological activities of this genus. The present study has resulted in the isolation and characterization of four new 39-42 and five known 43-47 flavonoides glycosides.

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Part B :Part-B of the thesis deals with bioactivity-guided isolation and identification of cholinesterase inhibiting constituents from a medicinally important plant, Cocculus pendulus. This includes two new 106-107 and ,seven known 108-114 bisbenzylisoquinoline alkaloids. These compounds were screened for their cholinesterase inhibitory activity by a mechanism-based assay. They were found to have ICso values ranging between 10.0-150.0 ┬ÁM.

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Part-C of the thesis describes the phytochemical investigation on the alkaloidal constituents of Aconitum karakolicum which resulted in the isolation and characterization of two new 162-163 and two known 164-165 diterpenoid alkaloids.

Section D-I : Compounds isolated from Iris germanica were assayed for their anti-oxidant activity in DPPH radical scavenging assay. They were found to have IC50 values between 0.0392-0.0737 mM.

Section D-II : This part discusses the inhibitory activities of the compounds isolated from Cocculus pendulus against cholinesterases enzyme, an effective mean for the therapy of Alzheimer's disease which initially concentrated on AChE inhibition. Some of these compounds exhibited significant activity, while others were found to have mild to moderate activities.

Download Full Thesis
5987.25 KB
S. No. Chapter Title of the Chapters Page Size (KB)
1 0 Contents
354.3 KB
2 1 Part-A: Phytochemical Investigation On Iris Germanica ( Linn.)
2035.43 KB
  1.1 General Introduction 1
  1.2 Introduction 5
  1.3 Results And Discussion 33
  1.4 Experimental 78
3 2 Part- B : Phytochemical Investigation On Cocculus Pendulus ( Forts. And Diels )
1310.93 KB
  2.1 Introduction 95
  2.2 Results And Discussion 116
  2.3 Experimental 142
4 3 Part-C Phtyochemical Investigation On Aconitum Karakolicumk ( Rapaics ) 156
1954.42 KB
  3.1 Introduction 156
  3.2 Results And Discussion 197
  3.3 Experimental 216
5 4 Part- D : Biological Activities Of Compounds Isolated From Iris Germanica And Cocculus Pendulus
618.25 KB
  4.1 Biological Activities 223
  4.2 Conclusion 234a
  4.3 Bibliography 243b
  4.4 Glossary 250
  4.5 List Of Publications 253