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| Pakistan Research Repository | Home |
Title of Thesis |
| Author(s) Afshan Begum |
| Institute/University/Department Details H.E.J. Research Institute of Chemistry / University of Karachi |
| Session 2007 |
| Subject Chemistry |
| Number of Pages 170 |
| Keywords (Extracted from title, table of contents and abstract of thesis) phytochemicals, biological assays, lindelofia stylosa, bergenia ciliate, trigonella foenum graecum, anti-glycatio assay |
Abstract PART A :This part of the thesis describes the isolation and structure elucidation of seven new 1-7 and thirteen known glycosides and phenyl polypropanoides 8-20 from Lindelofia stylosa (Kar. & Kir.). The compounds 1-20 were found to posse's immunomoduladatory activity, while compounds 9-19 exhibited a potent anti-oxidant activity (IC50 values between 0.04 to 0.27 µM). The new constituents were identified as 3-O-feruloyl-6'-O-coumaroyl sucrose (1), 3- O-feruloyl-6'-O-caffeoyl sucrose (2), 3,6-O-diferuloyl-l-kestose (3), 3-O-feruloyl-6'-O-coumaroyl-l-kestose (4), 3,6- O-diferuloyl nystose (5), 3-0-feruloyl-6'- O- coumaroyl nystose (6), and ethyllithospermate (7). ---------------------------------------------------------------Snaps----------------------------------------------------------- The structures of new compounds 1-7 were deduced on the basis of different spectroscopic techniques, including 1H- and 13C-NMR spectroscopy (HMQC, HMBC, ID-TOCSY, COSY 45°, etc). The known compounds 8-20 were isolated for the first time from Lindelofia stylosa and identified as 3,6'-O-diferuloylsucrose (8), 3-0-feruloyl fructofuranosyl sucrose (9), dimethyllithospermate (10), dimethyllithospermate B (11), rosmarinic acid (12), methyl rosmarinate (13), ethyl rosmarinate (14), butyl rosmarinate (15), p-coumaric acid (16), ferulic acid (17), 8-O-,B-D-glucopyranosyl torachrysone (18), naphthalene glycoside (8-O-,B-D-glucopyranoside) (19), and 4'-hydroxy-5-methoxy-6,7- methylenedioxyisoflavone (20). ---------------------------------------------------------------Snaps----------------------------------------------------------- PART B :Part B of the thesis describes the phytochemical investigation on Bergenia ciliate (How.) Stemb., which has resulted in the isolation of three known compounds, identified as bergenin (21), p-hydroxybenzoyl bergenin (22), and 11- O-galloyl bergenin (23). ---------------------------------------------------------------Snaps----------------------------------------------------------- PARTC : Part C of the thesis describes the isolation of secondary metabolites from Trigonella foenum-gracecum L. This has resulted in the isolation of two known constituents, identified as kaempferol-7 -O-α-rhamnoside (24) and kaempferol-3-O- α -L- rhamnopyranoside-7 -O- α -L-rhamnopyranoside (25) |
| Download Full Thesis |  3373.61 KB |
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| S. No. | Chapter | Title of the Chapters | Page | Size (KB) |
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| 1 | 0 | Contents | 306.46 KB |
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| 2 | 1 | General Introduction | 1 | 130.2 KB |
| 1.1 | Introduction | 1 | ||
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| 3 | 2 | Phtyochemical Investigation On Secondary Metabolites From Lindelofia Stylosa ( Kar . & Kir ) | 8 | 2140.17 KB |
| 2.1 | Introduction | 8 | ||
| 2.2 | Results And Discussion | 24 | ||
| 2.3 | Experimental | 87 | ||
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| 4 | 3 | Biological Activities On Compounds From Lindelofia Stylosa ( Kar . & Kir ) | 115 | 258.97 KB |
| 3.1 | Anti-Oxidant Activity | 115 | ||
| 3.2 | Immunomodulatory Activity | 120 | ||
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| 5 | 4 | Phytochemical Studies On Bergenia Ciliate (How.) Sternb | 127 | 224.62 KB |
| 4.1 | Introduction | 127 | ||
| 4.2 | Results And Discussion | 129 | ||
| 4.3 | Experimental | 134 | ||
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| 6 | 5 | Isolation Of Econdary Metabolites From Trigonella Foenum-Gracecum L. | 140 | 218.36 KB |
| 5.1 | Introduction | 140 | ||
| 5.2 | Results And Discussion | 143 | ||
| 5.3 | Experimental | 148 | ||
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| 7 | 6 | Biological Activities On Compounds Isolated From Trigonella Foenum Gracecum L. | 153 | 81.87 KB |
| 6.1 | Anti-Glycatio Assay | 153 | ||
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| 8 | 7 | References | 157 | 93.29 KB |
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| 9 | 8 | Glossary | 162 | 134.05 KB |
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| 10 | 9 | List Of Publications | 170 | 11.97 KB |
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