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Title of Thesis  
STUDIES ON THE CHEMICAL CONSTITUENTS WITHANIA COAGULANS AND BOSWELLIA DALZIELLI  
Author(s)  
ANIQA NAZ  
Institute/University/Department Details  
University of Karachi, Karachi/Chemistry  
Status (Published/ Not Published/ In Press etc)  
Published  
Date of Publishing  
2002  
Subject  
Chemistry  
Number of Pages  
174  
   
Keywords (Extracted from title, table of contents and abstract of thesis)  
Withania coagulans, Boswellia dalzielli, Withanolides, Coagulin J, Ajugin A, Methyl-4-benzoate, B-Amyrin, B-Sitosteral, B-Sitosteral glycoside, Boswellia dalzielli,  

 

 
Abstract  

This dissertation describes phytochemical studies on Withania coagulans and Boswellia dalzielli. The present work on these plants has resulted in the isolation of five new natural products. In addition to these, seven known compounds have been isolated and characterized for the first time from Withania coagulans, along with eight known compounds. The new constituents isolated from Withania coagulans were (22R), 20B-hydroxy-1-oxowitha-2, 5, 24-trienolide (90), coagulin J (91) [82], coagulin R (92) and coagulin U (93). Compounds 90 and 91 have also been isolated by our colleagues Dr. Dur-e-Shahwar Makhdoom and Dr. Muhammad Yousaf, respectively. The known compounds isolated from Withania coagulans for the first time were (22R)-14, 20-epoxy-17B-hydroxy-l-oxowitha-3, 5, 25-trienolide (96), (22R)-14, 20- epoxy-17B-hydroxy-1-oxowitha-5,24-dienolide-3B-(O-B-D-glucopyranoside) (94), ajugin A (102), methyl-4- benzoate (103), B-sitosterol (105), B-sitosterol glycoside (106) and B-amyrin (104). The known withanolides isolated were coagulin K (95), coagulin C (97), coagulin E (98), coagulin D (99), coagulin F (100) and coagulin B (101). A new compound isolated from Boswellia dalzielli was trans-3, 5-dihydroxy-4-methoxystilbene-3B-[O-B-D-glucopyranosyl (1-6)-a-L-rhamnopyranoside] (18). This compound was also found to be significantly active against the enzyme phosphodiesterase I. The structure elucidation of all compounds was carried out using different spectroscopic techniques including 1H- and 13C-NMR spectroscopy (HMQC, HMBC, COSY 45°, nOe, NOESY, HOHAHA etc.), mass spectrometry (E1, -ve and +ve FAB MS, FDMS etc.), 1R, UV, etc.

 
   
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Sr.No Chapter Table of Contents
 
i 180.kbs
111.KB
1 1

General Introduction

1
63.KB
2 2 Phytochemical Studies on Withania coagulans 9
241.KB
3 3 Results and Discussion 39
642.KB
4 4 Experimental 117
208.KB
5 5 Phytochemical Studies on Boswellia dalzielli 145
165.KB
6 6 Appendix I
21.KB
7 7 References 165
86.KB
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