I= CHEMICAL CONSTITUENTS OF STACHYS PARVIFLORA
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Title of Thesis
CHEMICAL CONSTITUENTS OF STACHYS PARVIFLORA

Author(s)
Saima Arshad
Institute/University/Department Details
H.E.J Research Institute of Chemistry/ University of Karachi
Session
2006
Subject
Number of Pages
145
Keywords (Extracted from title, table of contents and abstract of thesis)
stachys parviflora, lamiaceae, labiateae, benzene derivative, flavone glycoside, triterpenoidal saponins, monoterpenoids

Abstract
The work embodied in this dissertation is mainly concerned with the isolation and characterization of chemical constituents of Stachys parviflora, Linn., which belongs to the family Lamiaceae (formerly called Labiateae). The isolated compounds, whether new or have been previously reported in the literature, were characterized by using different spectroscopic techniques including IH NMR, 13C NMR, DEPT, HMQC, HMBC, COSY 45°,NOESY, El-MS, FAB-MS, IR and DV.

The studies on Stachys parviflora Linn., resulted in the isolation and characterization of thirteen compounds consisting of five new including one benzene derivative, one flavone glycoside and three triterpenoidal saponins, along with eight known compounds including two monoterpenoids, three flavone glycosides, one triterpene, two sterols and one steroidal saponin. All the known compounds have not been reported from this plant because no work was previously done on this specie of Stachys.

The new constituents isolated are parvifloroside B (55), stachyfloroside A (56), stachyssaponin A (57), stachyssaponin B (58) and stachyssaponin C (59). The new source compounds are harpagide (46), (3S, 5R, 6R, 7S, 9R) -3,5,6-trihydroxy- β -ionyl-9-0- β -D-glucopyranoside (47), 6-hydroxyluteolin 4'-methyl ether 7-O-(6"'-0-acetyl)- β-D-allopyranosyl- β-D-glucopyranoside (48), isoscutellarein-7 -0-(6"'-0 -acetyl)- β-D-allopyranosyl- β-D- glucopyranoside (49) hypolaetin 7-0-(6"'-0-acetyl)-β-D-allopyranosyl- β-D- glucopyranoside (50), oleanolic acid (51), lupeol (52), β-sitosterol (53) and β-sitosterol glycoside (54 ).

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S. No. Chapter Title of the Chapters Page Size (KB)
1 0 Contents
259.35 KB
2 1 Introduction 1
773.85 KB
  1.1 The Genus Stachys Linn. 1
  1.2 Botanical Description Of Stachy Parviflora 1
  1.3 The Biological Activities And Medicinal Uses Of The Genus Of Stachys 2
  1.4 Phytochemicals: Their Role In The Modern Times 4
  1.5 Naturally Occurring Glycoides 8
  1.6 Flavonoids 10
  1.7 Diversity And Importance Of Plant Phenolics 17
  1.8 Saponins 20
  1.9 Antioxidants 24
3 2 Biosynthesis 28
437.67 KB
  2.1 Individual Steps Of Flavonoid Classes 31
  2.2 Glycosylation Of Flavonoids 34
  2.3 Methylation Of Flavonoids 35
  2.4 Biosynthesis Of Aromatic Compounds 36
  2.5 Biosynthesis Of Gentisyl Alcohol 38
  2.6 Biosynthesis Of Saponins 45
4 3 Literature Review Of Stachts Spp .
112.09 KB
5 4 Results And Discussion 51
1351.67 KB
  4.1 Present Works 51
  4.2 Structure Elucidation Of The Chemical Constituents Of S.Parviflora 51
6 5 Experimental 110
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  5.1 General Experimental Procedure 110
  5.2 Acid Hydrolysis Of Compounds 111
  5.3 Materials For Antioxidant Activity 112
  5.4 Method 114
  5.5 Characterization Of Chemical Constituents Of Stachys Parviflora 118
  5.6 Antioxidant Activity Of 6-Hydroxy 4€™- O -Methyl Isoscutllarin-7- O €“(2€- O -6€- O - Acetyl) -’-D- Allopyranosyl - ’-D- Glucopyransoide (48) And Isoscutellarein-7- O €“(6€€™- O - Acetyl)-’-D- Allopyranosyl - ’-D- Glucopyransoide (49) 132
7 6 References 133
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