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Title of Thesis

Syed Javaid Khurshid
Institute/University/Department Details
University of the Punjab, Lahore
Number of Pages
Keywords (Extracted from title, table of contents and abstract of thesis)
schiff bases, transition metal complex, anthranilic acid, sugar, amino acids, chelates, sugar schiff base

This work aimed at preparation, characterization, and biologic evaluation of Schiff base transition metal complex derived from anthranilic acid-sugar and naturally occurring amino acids-sugar Schiff bases. In these complexes anthranilic acid and naturally occurring amino acids provide an amino group while aldoses provide an aldehyde group for Schiff base formation. These Schiff bases were obtained as chelates with transition metal ions: manganese (11) iron (II), cobalt (II), nickel (II), copper (II), and zinc (II),

A total of twenty-four anthranilic acid-sugar and eighty naturally occurring amino acid-sugar Schiff base metal complex were prepared and characterized by microanalysis; infrared, electronic absorption, and electron paramagnetic resonance spectrophotometer; magnetic moment, and thermal analysis. These complexes were obtained by the template method. These ML2 complex of manganese (II) and iron (II) were tetrahedral whereas cobalt (II), nickel (II), copper (II), and zinc (II) complex were planer.

These complexes were tested for their toxic effects and LD50 values were determined. Their antibacterial activities were determined against three standard strains of Escherichia coli (ATCC 25922), staphylococcus (ATCC 25923) and pseudomonas aeruginosa (ATCC 27853) bis (N-L-xyloseiminetyrosinato )2 copper, bis (N-L-xyloseimine-tyrosinato)2 zinc, bis (N-L-glucoseiminecystinato)2 copper, bis (N-L-lactoseiminecystinato)2 copper, and bis (N-L-glucoseimine-methioninato)2 copper showed good antibacterial activites, while complexes derived from anthbranilic acid were found to be moderately or less active. These complex were also tested for their anti-inflammatory activity in rats. Some of them showed significant anti-inflammatory activity.

Some of the Schiff bases were used to form 99Tcm complexes. The labeling efficiency was about 59%. Biodistributions of these complexes were studied in vitro and in vivo. It was found that 29-30% of the radioactivity was bonded to albumin, whereas 49-51% was bonded to globulins with 31-32% bonded to y-globulin. Biodistribution studies in rats and scintigraphy in rabbits showed the maximum uptake occurred in liver followed by kidneys indicating their potential as liver and renal scanning agents. These complexes were cleared from blood and kidneys within two hours.

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S. No. Chapter Title of the Chapters Page Size (KB)
1 0 Contents
82.94 KB
2 1 Introduction 4
462.71 KB
  1.1 Schiff Bases 4
  1.2 Biological Importance Of Schiff Bases 6
  1.3 Schiff Base Transition Metal Complexes 9
  1.4 Biological Significance Of Components Used For Derivation Of Schiff Base Complexes 13
  1.5 Interaction Of Amino Acids And Sugars 25
  1.6 Effect Of Chelation An Biological Activity 27
  1.7 Present Study 28
  1.8 Physical Techniques Used For Characterization 29
  1.9 Biological Evaluation Of Complexes 43
  1.10 Radiolabel Ling And Biodistribution 53
3 2 Experimental 55
361.57 KB
  2.1 Materials 55
  2.2 Methods 60
4 3 Results And Discussion 95
856.63 KB
  3.1 Anthranilic Acid-Sugar Schiff Base Transition Metal Complexes 95
  3.2 Amino Acid-Sugar Schiff Base Transition Metal Complexes 133
5 4 References 173
184.62 KB